Identification and guided treatment of ventricular dysfunction in general practice using B-type natriuretic peptide

Research output: Contribution to journalArticle


  • D Mant
  • P Glasziou
  • L Wright
  • R Hare
  • R Perera
  • M Cowie


BACKGROUND: B-type natriuretic peptide (BNP) is a blood test which detects ventricular wall stretch and is being increasingly used in primary care on limited evidence. AIM: To assess the practical implications and potential clinical benefit of measuring BNP to identify and guide the treatment of undiagnosed or under-treated ventricular dysfunction in at-risk patients. DESIGN OF STUDY: Screening study with single-arm intervention. SETTING: A total of 1918 patients with diabetes mellitus or ischaemic heart disease aged > or =65 years registered with 12 general practices were invited; 76 patients with elevated BNP underwent BNP-guided treatment titration. METHOD: Eligible patients were invited to attend for a blood test at their own practice; those with a persistently elevated plasma BNP concentration (>43.3 pmol/l) after repeat measurement were offered initiation or up-titration of treatment guided by remeasurement of BNP with a target concentration of


Original languageEnglish
Pages (from-to)393-9
Number of pages7
JournalBritish Journal of General Practice
Issue number551
Publication statusPublished - 1 Jan 2008

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