Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial

Research output: Contribution to journalArticlepeer-review

Standard

Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY) : a multicentre, randomised controlled trial. / El-Toukhy, Tarek; Campo, Rudi; Khalaf, Yacoub; Tabanelli, Carla; Gianaroli, Luca; Gordts, Sylvie; Gordts, Stephen; Mestdagh, Greet; Mardesic, Tonko; Voboril, Jan; Marchino, Gian Luigi; Benedetto, Chiara; Al-Shawaf, Talha; Sabatini, Luca; Seed, Paul T; Gergolet, Marco; Grimbizis, Grigoris; Harb, Hoda; Coomarasamy, Aravinthan.

In: The Lancet, Vol. 387, No. 10038, 25.06.2016, p. 2614-2621.

Research output: Contribution to journalArticlepeer-review

Harvard

El-Toukhy, T, Campo, R, Khalaf, Y, Tabanelli, C, Gianaroli, L, Gordts, S, Gordts, S, Mestdagh, G, Mardesic, T, Voboril, J, Marchino, GL, Benedetto, C, Al-Shawaf, T, Sabatini, L, Seed, PT, Gergolet, M, Grimbizis, G, Harb, H & Coomarasamy, A 2016, 'Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial', The Lancet, vol. 387, no. 10038, pp. 2614-2621. https://doi.org/10.1016/S0140-6736(16)00258-0

APA

El-Toukhy, T., Campo, R., Khalaf, Y., Tabanelli, C., Gianaroli, L., Gordts, S., Gordts, S., Mestdagh, G., Mardesic, T., Voboril, J., Marchino, G. L., Benedetto, C., Al-Shawaf, T., Sabatini, L., Seed, P. T., Gergolet, M., Grimbizis, G., Harb, H., & Coomarasamy, A. (2016). Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial. The Lancet, 387(10038), 2614-2621. https://doi.org/10.1016/S0140-6736(16)00258-0

Vancouver

El-Toukhy T, Campo R, Khalaf Y, Tabanelli C, Gianaroli L, Gordts S et al. Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial. The Lancet. 2016 Jun 25;387(10038):2614-2621. https://doi.org/10.1016/S0140-6736(16)00258-0

Author

El-Toukhy, Tarek ; Campo, Rudi ; Khalaf, Yacoub ; Tabanelli, Carla ; Gianaroli, Luca ; Gordts, Sylvie ; Gordts, Stephen ; Mestdagh, Greet ; Mardesic, Tonko ; Voboril, Jan ; Marchino, Gian Luigi ; Benedetto, Chiara ; Al-Shawaf, Talha ; Sabatini, Luca ; Seed, Paul T ; Gergolet, Marco ; Grimbizis, Grigoris ; Harb, Hoda ; Coomarasamy, Aravinthan. / Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY) : a multicentre, randomised controlled trial. In: The Lancet. 2016 ; Vol. 387, No. 10038. pp. 2614-2621.

Bibtex

@article{20a5193315884dcf8be5fbb016bebdbe,
title = "Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial",
abstract = "Background:The success rate of in vitro fertilisation remains modest and many patients undergo multiple treatment cycles. Previous studies suggested in vitro fertilisation outcome could be improved in patients who have experienced recurrent implantation failure if hysteroscopy was performed before starting a treatment cycle. However, those studies were of limited quality and a definitive randomised trial was needed. Methods:The TROPHY trial was a single-blind multi-centre randomised controlled trial conducted in eight hospitals in four European countries. Women who had normal ultrasound of the uterine cavity and history of two to four failed in vitro fertilisation cycles were randomised to have either outpatient hysteroscopy or no hysteroscopy in the month before starting the subsequent treatment cycle. The trial used allocation concealment and minimisation for key prognostic variables, including age, body mass index and basal follicle stimulating hormone level. The primary outcome was live birth rate. Secondary outcomes were pregnancy, implantation and miscarriage rates and hysteroscopy findings. The trial was registered on the ISRCTN Registry (#ISRCTN35859078).Findings: Seven hundred and two women younger than 38 years were randomly assigned between January 2010 and December 2013; 350 allocated to the outpatient hysteroscopy group and 352 to the control group. The live birth rate after in vitro fertilisation was 29% (102/350) in the hysteroscopy group and 29% (102/352) in the control group (relative risk [RR] 1·0; 95% confidence interval [CI] 0·79, 1·25, P=0·96). Hysteroscopy identified uterine abnormalities in 26% (85/323) of women. No hysteroscopy-related complications occurred. There were no significant differences in the pregnancy, implantation or miscarriage rates.Interpretation: Outpatient hysteroscopy before in vitro fertilisation treatment in women with normal ultrasound of the uterine cavity and a history of two to four failed in vitro fertilisation treatment cycles does not improve the live birth rate.Funding:The trial was funded by the European Society of Human Reproduction and Embryology, and the European Society for Gynaecological Endoscopy. ",
author = "Tarek El-Toukhy and Rudi Campo and Yacoub Khalaf and Carla Tabanelli and Luca Gianaroli and Sylvie Gordts and Stephen Gordts and Greet Mestdagh and Tonko Mardesic and Jan Voboril and Marchino, {Gian Luigi} and Chiara Benedetto and Talha Al-Shawaf and Luca Sabatini and Seed, {Paul T} and Marco Gergolet and Grigoris Grimbizis and Hoda Harb and Aravinthan Coomarasamy",
year = "2016",
month = jun,
day = "25",
doi = "10.1016/S0140-6736(16)00258-0",
language = "English",
volume = "387",
pages = "2614--2621",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier",
number = "10038",

}

RIS

TY - JOUR

T1 - Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY)

T2 - a multicentre, randomised controlled trial

AU - El-Toukhy, Tarek

AU - Campo, Rudi

AU - Khalaf, Yacoub

AU - Tabanelli, Carla

AU - Gianaroli, Luca

AU - Gordts, Sylvie

AU - Gordts, Stephen

AU - Mestdagh, Greet

AU - Mardesic, Tonko

AU - Voboril, Jan

AU - Marchino, Gian Luigi

AU - Benedetto, Chiara

AU - Al-Shawaf, Talha

AU - Sabatini, Luca

AU - Seed, Paul T

AU - Gergolet, Marco

AU - Grimbizis, Grigoris

AU - Harb, Hoda

AU - Coomarasamy, Aravinthan

PY - 2016/6/25

Y1 - 2016/6/25

N2 - Background:The success rate of in vitro fertilisation remains modest and many patients undergo multiple treatment cycles. Previous studies suggested in vitro fertilisation outcome could be improved in patients who have experienced recurrent implantation failure if hysteroscopy was performed before starting a treatment cycle. However, those studies were of limited quality and a definitive randomised trial was needed. Methods:The TROPHY trial was a single-blind multi-centre randomised controlled trial conducted in eight hospitals in four European countries. Women who had normal ultrasound of the uterine cavity and history of two to four failed in vitro fertilisation cycles were randomised to have either outpatient hysteroscopy or no hysteroscopy in the month before starting the subsequent treatment cycle. The trial used allocation concealment and minimisation for key prognostic variables, including age, body mass index and basal follicle stimulating hormone level. The primary outcome was live birth rate. Secondary outcomes were pregnancy, implantation and miscarriage rates and hysteroscopy findings. The trial was registered on the ISRCTN Registry (#ISRCTN35859078).Findings: Seven hundred and two women younger than 38 years were randomly assigned between January 2010 and December 2013; 350 allocated to the outpatient hysteroscopy group and 352 to the control group. The live birth rate after in vitro fertilisation was 29% (102/350) in the hysteroscopy group and 29% (102/352) in the control group (relative risk [RR] 1·0; 95% confidence interval [CI] 0·79, 1·25, P=0·96). Hysteroscopy identified uterine abnormalities in 26% (85/323) of women. No hysteroscopy-related complications occurred. There were no significant differences in the pregnancy, implantation or miscarriage rates.Interpretation: Outpatient hysteroscopy before in vitro fertilisation treatment in women with normal ultrasound of the uterine cavity and a history of two to four failed in vitro fertilisation treatment cycles does not improve the live birth rate.Funding:The trial was funded by the European Society of Human Reproduction and Embryology, and the European Society for Gynaecological Endoscopy.

AB - Background:The success rate of in vitro fertilisation remains modest and many patients undergo multiple treatment cycles. Previous studies suggested in vitro fertilisation outcome could be improved in patients who have experienced recurrent implantation failure if hysteroscopy was performed before starting a treatment cycle. However, those studies were of limited quality and a definitive randomised trial was needed. Methods:The TROPHY trial was a single-blind multi-centre randomised controlled trial conducted in eight hospitals in four European countries. Women who had normal ultrasound of the uterine cavity and history of two to four failed in vitro fertilisation cycles were randomised to have either outpatient hysteroscopy or no hysteroscopy in the month before starting the subsequent treatment cycle. The trial used allocation concealment and minimisation for key prognostic variables, including age, body mass index and basal follicle stimulating hormone level. The primary outcome was live birth rate. Secondary outcomes were pregnancy, implantation and miscarriage rates and hysteroscopy findings. The trial was registered on the ISRCTN Registry (#ISRCTN35859078).Findings: Seven hundred and two women younger than 38 years were randomly assigned between January 2010 and December 2013; 350 allocated to the outpatient hysteroscopy group and 352 to the control group. The live birth rate after in vitro fertilisation was 29% (102/350) in the hysteroscopy group and 29% (102/352) in the control group (relative risk [RR] 1·0; 95% confidence interval [CI] 0·79, 1·25, P=0·96). Hysteroscopy identified uterine abnormalities in 26% (85/323) of women. No hysteroscopy-related complications occurred. There were no significant differences in the pregnancy, implantation or miscarriage rates.Interpretation: Outpatient hysteroscopy before in vitro fertilisation treatment in women with normal ultrasound of the uterine cavity and a history of two to four failed in vitro fertilisation treatment cycles does not improve the live birth rate.Funding:The trial was funded by the European Society of Human Reproduction and Embryology, and the European Society for Gynaecological Endoscopy.

U2 - 10.1016/S0140-6736(16)00258-0

DO - 10.1016/S0140-6736(16)00258-0

M3 - Article

VL - 387

SP - 2614

EP - 2621

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 10038

ER -