Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions
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Hypoxia inducible factors in liver disease and hepatocellular carcinoma : current understanding and future directions. / Wilson, Garrick K.; Tennant, Daniel A.; Mckeating, Jane A.
In: Journal of Hepatology, Vol. 61, No. 6, 12.2014, p. 1397-1406.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Hypoxia inducible factors in liver disease and hepatocellular carcinoma
T2 - current understanding and future directions
AU - Wilson, Garrick K.
AU - Tennant, Daniel A.
AU - Mckeating, Jane A.
N1 - Copyright © 2014. Published by Elsevier B.V.
PY - 2014/12
Y1 - 2014/12
N2 - Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.
AB - Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.
KW - Hypoxia
KW - Viral hepatitis
KW - Inflammation
KW - HIF
KW - Liver
U2 - 10.1016/j.jhep.2014.08.025
DO - 10.1016/j.jhep.2014.08.025
M3 - Article
C2 - 25157983
VL - 61
SP - 1397
EP - 1406
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 6
ER -