Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

Research output: Contribution to journalArticle

Standard

Harvard

APA

Vancouver

Author

Bibtex

@article{b682cdb32ce1483a95df328716dabbbd,
title = "Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions",
abstract = "Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.",
keywords = "Hypoxia, Viral hepatitis, Inflammation, HIF, Liver",
author = "Wilson, {Garrick K.} and Tennant, {Daniel A.} and Mckeating, {Jane A.}",
note = "Copyright {\textcopyright} 2014. Published by Elsevier B.V.",
year = "2014",
month = dec
doi = "10.1016/j.jhep.2014.08.025",
language = "English",
volume = "61",
pages = "1397--1406",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Hypoxia inducible factors in liver disease and hepatocellular carcinoma

T2 - current understanding and future directions

AU - Wilson, Garrick K.

AU - Tennant, Daniel A.

AU - Mckeating, Jane A.

N1 - Copyright © 2014. Published by Elsevier B.V.

PY - 2014/12

Y1 - 2014/12

N2 - Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.

AB - Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.

KW - Hypoxia

KW - Viral hepatitis

KW - Inflammation

KW - HIF

KW - Liver

U2 - 10.1016/j.jhep.2014.08.025

DO - 10.1016/j.jhep.2014.08.025

M3 - Article

C2 - 25157983

VL - 61

SP - 1397

EP - 1406

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 6

ER -