Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

Research output: Contribution to journalArticle

Abstract

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.

Bibliographic note

Copyright © 2014. Published by Elsevier B.V.

Details

Original languageEnglish
Pages (from-to)1397-1406
Number of pages10
JournalJournal of Hepatology
Volume61
Issue number6
Early online date23 Aug 2014
Publication statusPublished - Dec 2014

Keywords

  • Hypoxia, Viral hepatitis, Inflammation, HIF, Liver