Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions
Research output: Contribution to journal › Article › peer-review
Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.
Copyright © 2014. Published by Elsevier B.V.
|Number of pages||10|
|Journal||Journal of Hepatology|
|Early online date||23 Aug 2014|
|Publication status||Published - Dec 2014|
- Hypoxia, Viral hepatitis, Inflammation, HIF, Liver