Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial

Katarina Witt; Lee Beresford; Siladitya  Bhattacharya; Kate Brian; Aravinthan Coomarasamy; Richard Hooper; Jackson Kirkman-Brown; Yakoub Khalaf; Sheena Lewis; Allan Pacey; Sue Pavitt; Robert West; David Miller

doi:10.1136/bmjopen-2016-012609

Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial

Katarina Witt, Lee Beresford, Siladitya Bhattacharya, Kate Brian, Aravinthan Coomarasamy, Richard Hooper, Jackson Kirkman-Brown, Yakoub Khalaf, Sheena Lewis, Allan Pacey, Sue Pavitt, Robert West, David Miller

Metabolism and Systems Research

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Abstract

The selection of a sperm with good genomic integrity is an important consideration
for improving Intra-Cytoplasmic Sperm Injection (ICSI) outcome. Current convention
selects sperm by vigour and morphology, but preliminary evidence suggests
selection based on hyaluronic acid bidning may be beneficial. The aim of the
HABSelect trial is to determine the efficacy of HA-selection of sperm versus
conventionally selected sperm prior to ICSI on live birth rate (LBR). The mechanistic
aim is to assess whether and how the chromatin state of HA-selected sperm
corresponds with clinical outcomes – clinical pregnancy rate (CPR), LBR and
pregnancy loss (PL).

Original language	English
Article number	e012609
Journal	BMJ open
Volume	6
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2016-012609
Publication status	Published - 1 Oct 2016

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Witt, K., Beresford, L., Bhattacharya, S., Brian, K., Coomarasamy, A., Hooper, R., Kirkman-Brown, J., Khalaf, Y., Lewis, S., Pacey, A., Pavitt, S., West, R., & Miller, D. (2016). Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial. BMJ open, 6(10), Article e012609. https://doi.org/10.1136/bmjopen-2016-012609

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abstract = "The selection of a sperm with good genomic integrity is an important considerationfor improving Intra-Cytoplasmic Sperm Injection (ICSI) outcome. Current conventionselects sperm by vigour and morphology, but preliminary evidence suggestsselection based on hyaluronic acid bidning may be beneficial. The aim of theHABSelect trial is to determine the efficacy of HA-selection of sperm versusconventionally selected sperm prior to ICSI on live birth rate (LBR). The mechanisticaim is to assess whether and how the chromatin state of HA-selected spermcorresponds with clinical outcomes – clinical pregnancy rate (CPR), LBR andpregnancy loss (PL).",

author = "Katarina Witt and Lee Beresford and Siladitya Bhattacharya and Kate Brian and Aravinthan Coomarasamy and Richard Hooper and Jackson Kirkman-Brown and Yakoub Khalaf and Sheena Lewis and Allan Pacey and Sue Pavitt and Robert West and David Miller",

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Witt, K, Beresford, L, Bhattacharya, S, Brian, K, Coomarasamy, A, Hooper, R, Kirkman-Brown, J, Khalaf, Y, Lewis, S, Pacey, A, Pavitt, S, West, R & Miller, D 2016, 'Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial', BMJ open, vol. 6, no. 10, e012609. https://doi.org/10.1136/bmjopen-2016-012609

TY - JOUR

T1 - Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial

AU - Witt, Katarina

AU - Beresford, Lee

AU - Bhattacharya, Siladitya

AU - Brian, Kate

AU - Coomarasamy, Aravinthan

AU - Hooper, Richard

AU - Kirkman-Brown, Jackson

AU - Khalaf, Yakoub

AU - Lewis, Sheena

AU - Pacey, Allan

AU - Pavitt, Sue

AU - West, Robert

AU - Miller, David

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The selection of a sperm with good genomic integrity is an important considerationfor improving Intra-Cytoplasmic Sperm Injection (ICSI) outcome. Current conventionselects sperm by vigour and morphology, but preliminary evidence suggestsselection based on hyaluronic acid bidning may be beneficial. The aim of theHABSelect trial is to determine the efficacy of HA-selection of sperm versusconventionally selected sperm prior to ICSI on live birth rate (LBR). The mechanisticaim is to assess whether and how the chromatin state of HA-selected spermcorresponds with clinical outcomes – clinical pregnancy rate (CPR), LBR andpregnancy loss (PL).

AB - The selection of a sperm with good genomic integrity is an important considerationfor improving Intra-Cytoplasmic Sperm Injection (ICSI) outcome. Current conventionselects sperm by vigour and morphology, but preliminary evidence suggestsselection based on hyaluronic acid bidning may be beneficial. The aim of theHABSelect trial is to determine the efficacy of HA-selection of sperm versusconventionally selected sperm prior to ICSI on live birth rate (LBR). The mechanisticaim is to assess whether and how the chromatin state of HA-selected spermcorresponds with clinical outcomes – clinical pregnancy rate (CPR), LBR andpregnancy loss (PL).

U2 - 10.1136/bmjopen-2016-012609

DO - 10.1136/bmjopen-2016-012609

M3 - Article

SN - 2044-6055

VL - 6

JO - BMJ open

JF - BMJ open

IS - 10

M1 - e012609

ER -

Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial

Abstract

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