Human tuberculosis predates domestication in ancient Syria

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Human tuberculosis predates domestication in ancient Syria. / Baker, Oussama; Lee, Oona Y.-c.; Wu, Houdini H.t.; Besra, Gurdyal S.; Minnikin, David E.; Llewellyn, Gareth; Williams, Christopher M.; Maixner, Frank; O'sullivan, Niall; Zink, Albert; Chamel, Bérénice; Khawam, Rima; Coqueugniot, Eric; Helmer, Daniel; Mort, Françoise L.e.; Perrin, Pascale; Gourichon, Lionel; Dutailly, Bruno; Pálfi, György; Coqueugniot, Hélène; Dutour, Olivier.

In: Tuberculosis, Vol. 95, No. Supplement 1, 06.2015, p. S4-12.

Research output: Contribution to journalArticlepeer-review

Harvard

Baker, O, Lee, OY, Wu, HHT, Besra, GS, Minnikin, DE, Llewellyn, G, Williams, CM, Maixner, F, O'sullivan, N, Zink, A, Chamel, B, Khawam, R, Coqueugniot, E, Helmer, D, Mort, FLE, Perrin, P, Gourichon, L, Dutailly, B, Pálfi, G, Coqueugniot, H & Dutour, O 2015, 'Human tuberculosis predates domestication in ancient Syria', Tuberculosis, vol. 95, no. Supplement 1, pp. S4-12. https://doi.org/10.1016/j.tube.2015.02.001

APA

Baker, O., Lee, O. Y., Wu, H. H. T., Besra, G. S., Minnikin, D. E., Llewellyn, G., Williams, C. M., Maixner, F., O'sullivan, N., Zink, A., Chamel, B., Khawam, R., Coqueugniot, E., Helmer, D., Mort, F. L. E., Perrin, P., Gourichon, L., Dutailly, B., Pálfi, G., ... Dutour, O. (2015). Human tuberculosis predates domestication in ancient Syria. Tuberculosis, 95(Supplement 1), S4-12. https://doi.org/10.1016/j.tube.2015.02.001

Vancouver

Author

Baker, Oussama ; Lee, Oona Y.-c. ; Wu, Houdini H.t. ; Besra, Gurdyal S. ; Minnikin, David E. ; Llewellyn, Gareth ; Williams, Christopher M. ; Maixner, Frank ; O'sullivan, Niall ; Zink, Albert ; Chamel, Bérénice ; Khawam, Rima ; Coqueugniot, Eric ; Helmer, Daniel ; Mort, Françoise L.e. ; Perrin, Pascale ; Gourichon, Lionel ; Dutailly, Bruno ; Pálfi, György ; Coqueugniot, Hélène ; Dutour, Olivier. / Human tuberculosis predates domestication in ancient Syria. In: Tuberculosis. 2015 ; Vol. 95, No. Supplement 1. pp. S4-12.

Bibtex

@article{dec50087e3ad4259979abdf9caaeb968,
title = "Human tuberculosis predates domestication in ancient Syria",
abstract = "The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.",
keywords = "Paleopathology of TB, early neolithic, PPNB, agriculture cradle, domestication, Lipid biomarkers, Ancient DNA",
author = "Oussama Baker and Lee, {Oona Y.-c.} and Wu, {Houdini H.t.} and Besra, {Gurdyal S.} and Minnikin, {David E.} and Gareth Llewellyn and Williams, {Christopher M.} and Frank Maixner and Niall O'sullivan and Albert Zink and B{\'e}r{\'e}nice Chamel and Rima Khawam and Eric Coqueugniot and Daniel Helmer and Mort, {Fran{\c c}oise L.e.} and Pascale Perrin and Lionel Gourichon and Bruno Dutailly and Gy{\"o}rgy P{\'a}lfi and H{\'e}l{\`e}ne Coqueugniot and Olivier Dutour",
year = "2015",
month = jun,
doi = "10.1016/j.tube.2015.02.001",
language = "English",
volume = "95",
pages = "S4--12",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Elsevier",
number = "Supplement 1",

}

RIS

TY - JOUR

T1 - Human tuberculosis predates domestication in ancient Syria

AU - Baker, Oussama

AU - Lee, Oona Y.-c.

AU - Wu, Houdini H.t.

AU - Besra, Gurdyal S.

AU - Minnikin, David E.

AU - Llewellyn, Gareth

AU - Williams, Christopher M.

AU - Maixner, Frank

AU - O'sullivan, Niall

AU - Zink, Albert

AU - Chamel, Bérénice

AU - Khawam, Rima

AU - Coqueugniot, Eric

AU - Helmer, Daniel

AU - Mort, Françoise L.e.

AU - Perrin, Pascale

AU - Gourichon, Lionel

AU - Dutailly, Bruno

AU - Pálfi, György

AU - Coqueugniot, Hélène

AU - Dutour, Olivier

PY - 2015/6

Y1 - 2015/6

N2 - The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

AB - The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

KW - Paleopathology of TB

KW - early neolithic

KW - PPNB

KW - agriculture cradle

KW - domestication

KW - Lipid biomarkers

KW - Ancient DNA

U2 - 10.1016/j.tube.2015.02.001

DO - 10.1016/j.tube.2015.02.001

M3 - Article

VL - 95

SP - S4-12

JO - Tuberculosis

JF - Tuberculosis

SN - 1472-9792

IS - Supplement 1

ER -