Human tuberculosis predates domestication in ancient Syria

Oussama Baker; Oona Y.-c. Lee; Houdini H.t. Wu; Gurdyal S. Besra; David E. Minnikin; Gareth Llewellyn; Christopher M. Williams; Frank Maixner; Niall O'sullivan; Albert Zink; Bérénice Chamel; Rima Khawam; Eric Coqueugniot; Daniel Helmer; Françoise L.e. Mort; Pascale Perrin; Lionel Gourichon; Bruno Dutailly; György Pálfi; Hélène Coqueugniot; Olivier Dutour

doi:10.1016/j.tube.2015.02.001

Human tuberculosis predates domestication in ancient Syria

Oussama Baker, Oona Y.-c. Lee, Houdini H.t. Wu, Gurdyal S. Besra, David E. Minnikin, Gareth Llewellyn, Christopher M. Williams, Frank Maixner, Niall O'sullivan, Albert Zink, Bérénice Chamel, Rima Khawam, Eric Coqueugniot, Daniel Helmer, Françoise L.e. Mort, Pascale Perrin, Lionel Gourichon, Bruno Dutailly, György Pálfi, Hélène CoqueugniotOlivier Dutour

Biosciences

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Abstract

The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

Original language	English
Pages (from-to)	S4-12
Journal	Tuberculosis
Volume	95
Issue number	Supplement 1
Early online date	26 Feb 2015
DOIs	https://doi.org/10.1016/j.tube.2015.02.001
Publication status	Published - Jun 2015

Keywords

Paleopathology of TB
early neolithic
PPNB
agriculture cradle
domestication
Lipid biomarkers
Ancient DNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2015.02.001

Baker_et_al_Human_tuberculosis_predates_domestication_ancient_Syria_Tuberculosis_2015
NOTICE: this is the author’s version of a work that was accepted for publication in Tuberculosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tuberculosis, DOI: 10.1016/j.tube.2015.02.001. Eligibility for repository checked April 2015
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Baker, O., Lee, O. Y., Wu, H. H. T., Besra, G. S., Minnikin, D. E., Llewellyn, G., Williams, C. M., Maixner, F., O'sullivan, N., Zink, A., Chamel, B., Khawam, R., Coqueugniot, E., Helmer, D., Mort, F. L. E., Perrin, P., Gourichon, L., Dutailly, B., Pálfi, G., ... Dutour, O. (2015). Human tuberculosis predates domestication in ancient Syria. Tuberculosis, 95(Supplement 1), S4-12. Advance online publication. https://doi.org/10.1016/j.tube.2015.02.001

@article{dec50087e3ad4259979abdf9caaeb968,

title = "Human tuberculosis predates domestication in ancient Syria",

abstract = "The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.",

keywords = "Paleopathology of TB, early neolithic, PPNB, agriculture cradle, domestication, Lipid biomarkers, Ancient DNA",

author = "Oussama Baker and Lee, {Oona Y.-c.} and Wu, {Houdini H.t.} and Besra, {Gurdyal S.} and Minnikin, {David E.} and Gareth Llewellyn and Williams, {Christopher M.} and Frank Maixner and Niall O'sullivan and Albert Zink and B{\'e}r{\'e}nice Chamel and Rima Khawam and Eric Coqueugniot and Daniel Helmer and Mort, {Fran{\c c}oise L.e.} and Pascale Perrin and Lionel Gourichon and Bruno Dutailly and Gy{\"o}rgy P{\'a}lfi and H{\'e}l{\`e}ne Coqueugniot and Olivier Dutour",

year = "2015",

month = jun,

doi = "10.1016/j.tube.2015.02.001",

language = "English",

volume = "95",

pages = "S4--12",

journal = "Tuberculosis",

issn = "1472-9792",

publisher = "Elsevier",

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Baker, O, Lee, OY, Wu, HHT, Besra, GS, Minnikin, DE, Llewellyn, G, Williams, CM, Maixner, F, O'sullivan, N, Zink, A, Chamel, B, Khawam, R, Coqueugniot, E, Helmer, D, Mort, FLE, Perrin, P, Gourichon, L, Dutailly, B, Pálfi, G, Coqueugniot, H & Dutour, O 2015, 'Human tuberculosis predates domestication in ancient Syria', Tuberculosis, vol. 95, no. Supplement 1, pp. S4-12. https://doi.org/10.1016/j.tube.2015.02.001

TY - JOUR

T1 - Human tuberculosis predates domestication in ancient Syria

AU - Baker, Oussama

AU - Lee, Oona Y.-c.

AU - Wu, Houdini H.t.

AU - Besra, Gurdyal S.

AU - Minnikin, David E.

AU - Llewellyn, Gareth

AU - Williams, Christopher M.

AU - Maixner, Frank

AU - O'sullivan, Niall

AU - Zink, Albert

AU - Chamel, Bérénice

AU - Khawam, Rima

AU - Coqueugniot, Eric

AU - Helmer, Daniel

AU - Mort, Françoise L.e.

AU - Perrin, Pascale

AU - Gourichon, Lionel

AU - Dutailly, Bruno

AU - Pálfi, György

AU - Coqueugniot, Hélène

AU - Dutour, Olivier

PY - 2015/6

Y1 - 2015/6

N2 - The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

AB - The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.

KW - Paleopathology of TB

KW - early neolithic

KW - PPNB

KW - agriculture cradle

KW - domestication

KW - Lipid biomarkers

KW - Ancient DNA

U2 - 10.1016/j.tube.2015.02.001

DO - 10.1016/j.tube.2015.02.001

M3 - Article

SN - 1472-9792

VL - 95

SP - S4-12

JO - Tuberculosis

JF - Tuberculosis

IS - Supplement 1

ER -

Human tuberculosis predates domestication in ancient Syria

Abstract

Keywords

UN SDGs

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