TY - JOUR
T1 - Human innate immunosenescence: causes and consequences for immunity in old age
AU - Panda, A
AU - Arjona, A
AU - Sapey, Elizabeth
AU - Bai, F
AU - Fikrig, E
AU - Montgomery, RR
AU - Lord, Janet
AU - Shaw, AC
PY - 2009/7/1
Y1 - 2009/7/1
N2 - The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing and activation of proinflammatory or antiviral cytokine production, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, natural killer and natural killer T (NKT) cells and dendritic cells-with a focus on consequences for the response to infection or vaccination in old age.
AB - The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing and activation of proinflammatory or antiviral cytokine production, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, natural killer and natural killer T (NKT) cells and dendritic cells-with a focus on consequences for the response to infection or vaccination in old age.
U2 - 10.1016/j.it.2009.05.004
DO - 10.1016/j.it.2009.05.004
M3 - Review article
C2 - 19541535
SN - 1471-4981
VL - 30
SP - 325
EP - 333
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -