Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy

Research output: Contribution to journalReview articlepeer-review

Standard

Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy. / Seranova, Elena; Palhegyi, Adina Maria; Verma, Surbhi; Dimova, Simona; Lasry, Rachel; Naama, Moriyah; Sun, Congxin; Barrett, Timothy; Rosenstock, Tatiana Rosado; Kumar, Dhiraj; Cohen, Malkiel A; Buganim, Yosef; Sarkar, Sovan.

In: Journal of Molecular Biology, Vol. 432, No. 8, 03.04.2020, p. 2754-2798.

Research output: Contribution to journalReview articlepeer-review

Harvard

Seranova, E, Palhegyi, AM, Verma, S, Dimova, S, Lasry, R, Naama, M, Sun, C, Barrett, T, Rosenstock, TR, Kumar, D, Cohen, MA, Buganim, Y & Sarkar, S 2020, 'Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy', Journal of Molecular Biology, vol. 432, no. 8, pp. 2754-2798. https://doi.org/10.1016/j.jmb.2020.01.024

APA

Seranova, E., Palhegyi, A. M., Verma, S., Dimova, S., Lasry, R., Naama, M., Sun, C., Barrett, T., Rosenstock, T. R., Kumar, D., Cohen, M. A., Buganim, Y., & Sarkar, S. (2020). Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy. Journal of Molecular Biology, 432(8), 2754-2798. https://doi.org/10.1016/j.jmb.2020.01.024

Vancouver

Author

Seranova, Elena ; Palhegyi, Adina Maria ; Verma, Surbhi ; Dimova, Simona ; Lasry, Rachel ; Naama, Moriyah ; Sun, Congxin ; Barrett, Timothy ; Rosenstock, Tatiana Rosado ; Kumar, Dhiraj ; Cohen, Malkiel A ; Buganim, Yosef ; Sarkar, Sovan. / Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy. In: Journal of Molecular Biology. 2020 ; Vol. 432, No. 8. pp. 2754-2798.

Bibtex

@article{4868697bc3c244e2b924e419d9a3f217,
title = "Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy",
abstract = "Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons. Improper functioning of this process contributes to the pathology of myriad human diseases, including neurodegeneration. Impairment in autophagy has been reported in several neurodegenerative diseases where pharmacological induction of autophagy has therapeutic benefits in cellular and transgenic animal models. However, emerging studies suggest that the efficacy of autophagy inducers, as well as the nature of the autophagy defects, may be context-dependent, and therefore, studies in disease-relevant experimental systems may provide more insights for clinical translation to patients. With the advancements in human stem cell technology, it is now possible to establish disease-affected cellular platforms from patients for investigating disease mechanisms and identifying candidate drugs in the appropriate cell types, such as neurons that are otherwise not accessible. Towards this, patient-derived human induced pluripotent stem cells (hiPSCs) have demonstrated considerable promise in constituting a platform for effective disease modeling and drug discovery. Multiple studies have utilized hiPSC models of neurodegenerative diseases to study autophagy and evaluate the therapeutic efficacy of autophagy inducers in neuronal cells. This review provides an overview of the regulation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differentiation. It outlines the findings in various neurodegenerative disorders where autophagy has been studied using hiPSC models.",
keywords = "autophagy, autophagy inducer, human induced pluripotent stem cells, neurodegenerative disease, neuronal differentiation",
author = "Elena Seranova and Palhegyi, {Adina Maria} and Surbhi Verma and Simona Dimova and Rachel Lasry and Moriyah Naama and Congxin Sun and Timothy Barrett and Rosenstock, {Tatiana Rosado} and Dhiraj Kumar and Cohen, {Malkiel A} and Yosef Buganim and Sovan Sarkar",
year = "2020",
month = apr,
day = "3",
doi = "10.1016/j.jmb.2020.01.024",
language = "English",
volume = "432",
pages = "2754--2798",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy

AU - Seranova, Elena

AU - Palhegyi, Adina Maria

AU - Verma, Surbhi

AU - Dimova, Simona

AU - Lasry, Rachel

AU - Naama, Moriyah

AU - Sun, Congxin

AU - Barrett, Timothy

AU - Rosenstock, Tatiana Rosado

AU - Kumar, Dhiraj

AU - Cohen, Malkiel A

AU - Buganim, Yosef

AU - Sarkar, Sovan

PY - 2020/4/3

Y1 - 2020/4/3

N2 - Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons. Improper functioning of this process contributes to the pathology of myriad human diseases, including neurodegeneration. Impairment in autophagy has been reported in several neurodegenerative diseases where pharmacological induction of autophagy has therapeutic benefits in cellular and transgenic animal models. However, emerging studies suggest that the efficacy of autophagy inducers, as well as the nature of the autophagy defects, may be context-dependent, and therefore, studies in disease-relevant experimental systems may provide more insights for clinical translation to patients. With the advancements in human stem cell technology, it is now possible to establish disease-affected cellular platforms from patients for investigating disease mechanisms and identifying candidate drugs in the appropriate cell types, such as neurons that are otherwise not accessible. Towards this, patient-derived human induced pluripotent stem cells (hiPSCs) have demonstrated considerable promise in constituting a platform for effective disease modeling and drug discovery. Multiple studies have utilized hiPSC models of neurodegenerative diseases to study autophagy and evaluate the therapeutic efficacy of autophagy inducers in neuronal cells. This review provides an overview of the regulation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differentiation. It outlines the findings in various neurodegenerative disorders where autophagy has been studied using hiPSC models.

AB - Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons. Improper functioning of this process contributes to the pathology of myriad human diseases, including neurodegeneration. Impairment in autophagy has been reported in several neurodegenerative diseases where pharmacological induction of autophagy has therapeutic benefits in cellular and transgenic animal models. However, emerging studies suggest that the efficacy of autophagy inducers, as well as the nature of the autophagy defects, may be context-dependent, and therefore, studies in disease-relevant experimental systems may provide more insights for clinical translation to patients. With the advancements in human stem cell technology, it is now possible to establish disease-affected cellular platforms from patients for investigating disease mechanisms and identifying candidate drugs in the appropriate cell types, such as neurons that are otherwise not accessible. Towards this, patient-derived human induced pluripotent stem cells (hiPSCs) have demonstrated considerable promise in constituting a platform for effective disease modeling and drug discovery. Multiple studies have utilized hiPSC models of neurodegenerative diseases to study autophagy and evaluate the therapeutic efficacy of autophagy inducers in neuronal cells. This review provides an overview of the regulation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differentiation. It outlines the findings in various neurodegenerative disorders where autophagy has been studied using hiPSC models.

KW - autophagy

KW - autophagy inducer

KW - human induced pluripotent stem cells

KW - neurodegenerative disease

KW - neuronal differentiation

U2 - 10.1016/j.jmb.2020.01.024

DO - 10.1016/j.jmb.2020.01.024

M3 - Review article

C2 - 32044344

VL - 432

SP - 2754

EP - 2798

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

SN - 0022-2836

IS - 8

ER -