Human aquaporins : regulators of transcellular water flow

Research output: Contribution to journalArticle

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Human aquaporins : regulators of transcellular water flow. / Day, Rebecca E.; Kitchen, Philip; Owen, David S.; Bland, Charlotte; Marshall, Lindsay; Conner, Alex C.; Bill, Roslyn M.; Conner, Matthew T.

In: Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1840, No. 5, 01.05.2014, p. 1492-1506.

Research output: Contribution to journalArticle

Harvard

Day, RE, Kitchen, P, Owen, DS, Bland, C, Marshall, L, Conner, AC, Bill, RM & Conner, MT 2014, 'Human aquaporins : regulators of transcellular water flow', Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1840, no. 5, pp. 1492-1506. https://doi.org/10.1016/j.bbagen.2013.09.033

APA

Day, R. E., Kitchen, P., Owen, D. S., Bland, C., Marshall, L., Conner, A. C., Bill, R. M., & Conner, M. T. (2014). Human aquaporins : regulators of transcellular water flow. Biochimica et Biophysica Acta (BBA) - General Subjects, 1840(5), 1492-1506. https://doi.org/10.1016/j.bbagen.2013.09.033

Vancouver

Author

Day, Rebecca E. ; Kitchen, Philip ; Owen, David S. ; Bland, Charlotte ; Marshall, Lindsay ; Conner, Alex C. ; Bill, Roslyn M. ; Conner, Matthew T. / Human aquaporins : regulators of transcellular water flow. In: Biochimica et Biophysica Acta (BBA) - General Subjects. 2014 ; Vol. 1840, No. 5. pp. 1492-1506.

Bibtex

@article{13718e2eb34449dc867b35cba83a3d9f,
title = "Human aquaporins : regulators of transcellular water flow",
abstract = "BackgroundEmerging evidence supports the view that (AQP) aquaporin water channels are regulators of transcellular water flow. Consistent with their expression in most tissues, AQPs are associated with diverse physiological and pathophysiological processes.Scope of reviewAQP knockout studies suggest that the regulatory role of AQPs, rather than their action as passive channels, is their critical function. Transport through all AQPs occurs by a common passive mechanism, but their regulation and cellular distribution varies significantly depending on cell and tissue type; the role of AQPs in cell volume regulation (CVR) is particularly notable. This review examines the regulatory role of AQPs in transcellular water flow, especially in CVR. We focus on key systems of the human body, encompassing processes as diverse as urine concentration in the kidney to clearance of brain oedema.Major conclusionsAQPs are crucial for the regulation of water homeostasis, providing selective pores for the rapid movement of water across diverse cell membranes and playing regulatory roles in CVR. Gating mechanisms have been proposed for human AQPs, but have only been reported for plant and microbial AQPs. Consequently, it is likely that the distribution and abundance of AQPs in a particular membrane is the determinant of membrane water permeability and a regulator of transcellular water flow.General significanceElucidating the mechanisms that regulate transcellular water flow will improve our understanding of the human body in health and disease. The central role of specific AQPs in regulating water homeostasis will provide routes to a range of novel therapies. This article is part of a Special Issue entitled Aquaporins.",
keywords = "Aquaporin regulation, Transcellular water flow, Homeostasis, Cell volume regulation, Regulatory volume increase, Regulatory volume decrease",
author = "Day, {Rebecca E.} and Philip Kitchen and Owen, {David S.} and Charlotte Bland and Lindsay Marshall and Conner, {Alex C.} and Bill, {Roslyn M.} and Conner, {Matthew T.}",
year = "2014",
month = may,
day = "1",
doi = "10.1016/j.bbagen.2013.09.033",
language = "English",
volume = "1840",
pages = "1492--1506",
journal = "Biochimica et Biophysica Acta (BBA) - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Human aquaporins : regulators of transcellular water flow

AU - Day, Rebecca E.

AU - Kitchen, Philip

AU - Owen, David S.

AU - Bland, Charlotte

AU - Marshall, Lindsay

AU - Conner, Alex C.

AU - Bill, Roslyn M.

AU - Conner, Matthew T.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - BackgroundEmerging evidence supports the view that (AQP) aquaporin water channels are regulators of transcellular water flow. Consistent with their expression in most tissues, AQPs are associated with diverse physiological and pathophysiological processes.Scope of reviewAQP knockout studies suggest that the regulatory role of AQPs, rather than their action as passive channels, is their critical function. Transport through all AQPs occurs by a common passive mechanism, but their regulation and cellular distribution varies significantly depending on cell and tissue type; the role of AQPs in cell volume regulation (CVR) is particularly notable. This review examines the regulatory role of AQPs in transcellular water flow, especially in CVR. We focus on key systems of the human body, encompassing processes as diverse as urine concentration in the kidney to clearance of brain oedema.Major conclusionsAQPs are crucial for the regulation of water homeostasis, providing selective pores for the rapid movement of water across diverse cell membranes and playing regulatory roles in CVR. Gating mechanisms have been proposed for human AQPs, but have only been reported for plant and microbial AQPs. Consequently, it is likely that the distribution and abundance of AQPs in a particular membrane is the determinant of membrane water permeability and a regulator of transcellular water flow.General significanceElucidating the mechanisms that regulate transcellular water flow will improve our understanding of the human body in health and disease. The central role of specific AQPs in regulating water homeostasis will provide routes to a range of novel therapies. This article is part of a Special Issue entitled Aquaporins.

AB - BackgroundEmerging evidence supports the view that (AQP) aquaporin water channels are regulators of transcellular water flow. Consistent with their expression in most tissues, AQPs are associated with diverse physiological and pathophysiological processes.Scope of reviewAQP knockout studies suggest that the regulatory role of AQPs, rather than their action as passive channels, is their critical function. Transport through all AQPs occurs by a common passive mechanism, but their regulation and cellular distribution varies significantly depending on cell and tissue type; the role of AQPs in cell volume regulation (CVR) is particularly notable. This review examines the regulatory role of AQPs in transcellular water flow, especially in CVR. We focus on key systems of the human body, encompassing processes as diverse as urine concentration in the kidney to clearance of brain oedema.Major conclusionsAQPs are crucial for the regulation of water homeostasis, providing selective pores for the rapid movement of water across diverse cell membranes and playing regulatory roles in CVR. Gating mechanisms have been proposed for human AQPs, but have only been reported for plant and microbial AQPs. Consequently, it is likely that the distribution and abundance of AQPs in a particular membrane is the determinant of membrane water permeability and a regulator of transcellular water flow.General significanceElucidating the mechanisms that regulate transcellular water flow will improve our understanding of the human body in health and disease. The central role of specific AQPs in regulating water homeostasis will provide routes to a range of novel therapies. This article is part of a Special Issue entitled Aquaporins.

KW - Aquaporin regulation

KW - Transcellular water flow

KW - Homeostasis

KW - Cell volume regulation

KW - Regulatory volume increase

KW - Regulatory volume decrease

U2 - 10.1016/j.bbagen.2013.09.033

DO - 10.1016/j.bbagen.2013.09.033

M3 - Article

VL - 1840

SP - 1492

EP - 1506

JO - Biochimica et Biophysica Acta (BBA) - General Subjects

JF - Biochimica et Biophysica Acta (BBA) - General Subjects

SN - 0304-4165

IS - 5

ER -