How to interpret randomised trials of test-treatment combinations: a critical evaluation of research on uterine Doppler test to predict, and aspirin to prevent, pre-eclampsia

Research output: Contribution to journalReview article

Colleges, School and Institutes


The methodology to evaluate either a test or treatment is well developed and understood. However, the design, conduct and interpretation of a combination of a test and a treatment in a single study are fraught with complexities. There are two distinct study designs to evaluate test-treatment combinations, with randomisation occurring either before or after the test. We present critical issues that need to be considered when evaluating and appraising test-treatment combinations, using the example of research on the uterine artery Doppler test to predict, and aspirin to prevent, pre-eclampsia.


Original languageEnglish
Pages (from-to)801-808
Number of pages8
Issue number7
Publication statusPublished - 1 Jun 2010


  • aspirin, pre-eclampsia, uterine artery doppler, test-treatment combinations