How to design a dose-finding study using the continual reassessment method

Research output: Contribution to journalArticle

Authors

  • Graham M Wheeler
  • Adrian P Mander
  • Alun W Bedding
  • Victoria Cornelius
  • Andrew Grieve
  • Thomas Jaki
  • Sharon B Love
  • Lang'o Odondi
  • Christopher J Weir
  • Simon J Bond

Colleges, School and Institutes

Abstract

Introduction: The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 design, which is used in most phase I trials. Furthermore, the CRM has been shown to assign more trial participants at or close to the MTD than the 3 + 3 design. However, the CRM's uptake in clinical research has been incredibly slow, putting trial participants, drug development and patients at risk. Barriers to increasing the use of the CRM have been identified, most notably a lack of knowledge amongst clinicians and statisticians on how to apply new designs in practice. No recent tutorial, guidelines, or recommendations for clinicians on conducting dose-finding studies using the CRM are available. Furthermore, practical resources to support clinicians considering the CRM for their trials are scarce. Methods: To help overcome these barriers, we present a structured framework for designing a dose-finding study using the CRM. We give recommendations for key design parameters and advise on conducting pre-trial simulation work to tailor the design to a specific trial. We provide practical tools to support clinicians and statisticians, including software recommendations, and template text and tables that can be edited and inserted into a trial protocol. We also give guidance on how to conduct and report dose-finding studies using the CRM. Results: An initial set of design recommendations are provided to kick-start the design process. To complement these and the additional resources, we describe two published dose-finding trials that used the CRM. We discuss their designs, how they were conducted and analysed, and compare them to what would have happened under a 3 + 3 design. Conclusions: The framework and resources we provide are aimed at clinicians and statisticians new to the CRM design. Provision of key resources in this contemporary guidance paper will hopefully improve the uptake of the CRM in phase I dose-finding trials.

Details

Original languageEnglish
Article number18
Number of pages15
JournalBMC Medical Research Methodology
Volume19
Issue number1
Publication statusPublished - 18 Jan 2019

Keywords

  • Adaptive designs, Continual reassessment method, Dose escalation, Dose-finding, Maximum tolerated dose, Phase I trials

ASJC Scopus subject areas