How HSCs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective

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How HSCs colonize and expand in the fetal niche of the vertebrate embryo : an evolutionary perspective. / Mahony, CB; Bertrand, JY.

In: Frontiers in cell and developmental biology, Vol. 7, 34, 12.03.2019.

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@article{555690b4eea64e6e9a8114e7445892b2,
title = "How HSCs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective",
abstract = "Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex vivo, creating a need to further understand HSC expansion in vivo. After embryonic HSCs are born from the hemogenic endothelium, they migrate to the embryonic/fetal niche, where the future adult HSC pool is established by considerable expansion. This takes place at different anatomical sites and is controlled by numerous signals. HSCs then migrate to their adult niche, where they are maintained throughout adulthood. Exactly how HSC expansion is controlled during embryogenesis remains to be characterized and is an important step to improve the therapeutic use of HSCs. We will review the current knowledge of HSC expansion in the different fetal niches across several model organisms and highlight possible clinical applications. ",
keywords = "zebrafish, mammals, CHT, fetal liver, hematopoietic (stem) cells, caudal hematopoietic tissue, microenvironment",
author = "CB Mahony and JY Bertrand",
year = "2019",
month = mar,
day = "12",
doi = "10.3389/fcell.2019.00034",
language = "English",
volume = "7",
journal = "Frontiers in cell and developmental biology",
issn = "2296-634X",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - How HSCs colonize and expand in the fetal niche of the vertebrate embryo

T2 - an evolutionary perspective

AU - Mahony, CB

AU - Bertrand, JY

PY - 2019/3/12

Y1 - 2019/3/12

N2 - Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex vivo, creating a need to further understand HSC expansion in vivo. After embryonic HSCs are born from the hemogenic endothelium, they migrate to the embryonic/fetal niche, where the future adult HSC pool is established by considerable expansion. This takes place at different anatomical sites and is controlled by numerous signals. HSCs then migrate to their adult niche, where they are maintained throughout adulthood. Exactly how HSC expansion is controlled during embryogenesis remains to be characterized and is an important step to improve the therapeutic use of HSCs. We will review the current knowledge of HSC expansion in the different fetal niches across several model organisms and highlight possible clinical applications.

AB - Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex vivo, creating a need to further understand HSC expansion in vivo. After embryonic HSCs are born from the hemogenic endothelium, they migrate to the embryonic/fetal niche, where the future adult HSC pool is established by considerable expansion. This takes place at different anatomical sites and is controlled by numerous signals. HSCs then migrate to their adult niche, where they are maintained throughout adulthood. Exactly how HSC expansion is controlled during embryogenesis remains to be characterized and is an important step to improve the therapeutic use of HSCs. We will review the current knowledge of HSC expansion in the different fetal niches across several model organisms and highlight possible clinical applications.

KW - zebrafish

KW - mammals

KW - CHT

KW - fetal liver

KW - hematopoietic (stem) cells

KW - caudal hematopoietic tissue

KW - microenvironment

UR - http://europepmc.org/abstract/med/30915333

U2 - 10.3389/fcell.2019.00034

DO - 10.3389/fcell.2019.00034

M3 - Review article

C2 - 30915333

VL - 7

JO - Frontiers in cell and developmental biology

JF - Frontiers in cell and developmental biology

SN - 2296-634X

M1 - 34

ER -