Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline

Maria Fleseriu, Niki Karavitaki

Research output: Contribution to journalArticlepeer-review

257 Citations (Scopus)
336 Downloads (Pure)

Abstract

Objective: The objective is to formulate clinical practice guidelines for hormonal replacement in hypopituitarism in adults. Participants: The participants include an Endocrine Society-appointed Task Force of six experts, a methodologist, and a medical writer. The American Association for Clinical Chemistry, The Pituitary Society, and the European Society of Endocrinology co-sponsored this guideline. Evidence: The Task Force developed this evidence-based guideline using the Grading of Recommendations, Assessment, Development, and Evaluation system to describe the strength of recommendations and the quality of evidence. The Task Force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Committees and members of the Endocrine Society, the American Association for Clinical Chemistry, The Pituitary Society, and the European Society of Endocrinology reviewed and commented on preliminary drafts of these guidelines. Conclusions: Using an evidence-based approach, this guideline addresses important clinical issues regarding the evaluation and management of hypopituitarism in adults, including appropriate biochemical assessments; specific therapeutic decisions to decrease the risk of co-morbidities due to hormonal overreplacement or under-replacement; and managing hypopituitarism during pregnancy, pituitary surgery, and other types of surgeries.
Original languageEnglish
Pages (from-to)3888-3921
JournalThe Journal of clinical endocrinology and metabolism
Volume101
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016

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