Homozygous deletions at 3p12 in breast and lung cancer

V Sundaresan, G Chung, A Heppell-Parton, Jie Xiong, C Grundy, I Roberts, L James, A Cahn, J Douglas, MI Minna, Y Sekido, MI Lerman, Farida Latif, J Bergh, H Li, N Lowe, D Ogilvie, P Rabbitts

    Research output: Contribution to journalArticle

    91 Citations (Scopus)

    Abstract

    We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.
    Original languageEnglish
    Pages (from-to)1723-9
    Number of pages7
    JournalOncogene
    Volume17
    Issue number13
    Early online date1 Oct 1998
    DOIs
    Publication statusPublished - 1 Oct 1998

    Fingerprint

    Dive into the research topics of 'Homozygous deletions at 3p12 in breast and lung cancer'. Together they form a unique fingerprint.

    Cite this