High-resolution computed tomography scanning in alpha-1-antitrypsin deficiency: relationship to lung function and health status

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Colleges, School and Institutes


The development of computed tomography (CT) has enabled emphysema to be assessed noninvasively. Objective quantification of lung density correlates well with lung function in patients with chronic obstructive pulmonary disease and has been shown to be a sensitive tool for monitoring disease progression. In order to determine the clinical impact of changes seen on high-resolution computed tomography (HRCT), the relationship between the objective quantification of emphysema on HRCT, lung function and health status in 111 patients with alpha (1)-antitrypsin deficiency, was examined (PiZ), The degree of HRCT scan abnormality correlated well (p


Original languageEnglish
Pages (from-to)1097-1104
Number of pages8
JournalThe European respiratory journal
Issue number6
Publication statusPublished - 1 Jun 2001


  • respiratory function tests, alpha(1)-antitrypsin deficiency, computed tomography, pulmonary emphysema, health status, obstructive lung disease