High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia

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High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia. / Ward, C.; Cauchy, P.; Garcia, P.; Frampton, J.; Esteban, M. A.; Volpe, G.

In: Scientific Reports, Vol. 10, No. 1, 3505, 26.02.2020.

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@article{05076c171c22474194a6a751486ad219,
title = "High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia",
abstract = "WW domain binding protein 5 (WBP5), also known as Transcriptional Elongation Factor A like 9 (TCEAL9) has been proposed as a candidate oncogene for human colorectal cancers with microsatellite instability and as a predictive indicator of small cell lung cancers. Furthermore, several independent studies have proposed WBP5, and its association with Wilms Tumor-1 (WT1) expression, as part of a gene expression-based risk score for predicting survival and clinical outcome in patients with Acute Myeloid Leukaemia (AML). To date, the prognostic significance of the sole WBP5 expression and its impact on the survival outcome in AML patients remains largely understudied. In the present study, we have made use of publicly available patient expression arrays and have developed an unbiased approach to classify AML patients into low versus high WBP5 expressers and to balance them for known mutations and cytogenetic findings. Interestingly, we found that patients characterized by high WBP5 expression displayed inferior overall and event-free survival rates. Notably, gene expression profiling showed that patients with high WBP5 had elevated expression of several HOX cluster genes, such as HOXA5, HOXA7, HOXA9 and HOXA10, and several of their partner proteins, such as MEIS1 and FOXC1, which have been demonstrated to be causative for AML. Taken together, our data suggest that WBP5 expression level could serve as an indicator for prognosis and survival outcome in patients with AML.",
keywords = "Biomarkers, Tumor/metabolism, Cluster Analysis, Forkhead Transcription Factors/metabolism, Homeodomain Proteins/genetics, Humans, Kaplan-Meier Estimate, Karyotype, Leukemia, Myeloid, Acute/metabolism, Multigene Family, Myeloid Ecotropic Viral Integration Site 1 Protein/metabolism, Nuclear Proteins/genetics, Prognosis, Progression-Free Survival, Transcriptome, Up-Regulation",
author = "C. Ward and P. Cauchy and P. Garcia and J. Frampton and Esteban, {M. A.} and G. Volpe",
year = "2020",
month = feb,
day = "26",
doi = "10.1038/s41598-020-60480-x",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia

AU - Ward, C.

AU - Cauchy, P.

AU - Garcia, P.

AU - Frampton, J.

AU - Esteban, M. A.

AU - Volpe, G.

PY - 2020/2/26

Y1 - 2020/2/26

N2 - WW domain binding protein 5 (WBP5), also known as Transcriptional Elongation Factor A like 9 (TCEAL9) has been proposed as a candidate oncogene for human colorectal cancers with microsatellite instability and as a predictive indicator of small cell lung cancers. Furthermore, several independent studies have proposed WBP5, and its association with Wilms Tumor-1 (WT1) expression, as part of a gene expression-based risk score for predicting survival and clinical outcome in patients with Acute Myeloid Leukaemia (AML). To date, the prognostic significance of the sole WBP5 expression and its impact on the survival outcome in AML patients remains largely understudied. In the present study, we have made use of publicly available patient expression arrays and have developed an unbiased approach to classify AML patients into low versus high WBP5 expressers and to balance them for known mutations and cytogenetic findings. Interestingly, we found that patients characterized by high WBP5 expression displayed inferior overall and event-free survival rates. Notably, gene expression profiling showed that patients with high WBP5 had elevated expression of several HOX cluster genes, such as HOXA5, HOXA7, HOXA9 and HOXA10, and several of their partner proteins, such as MEIS1 and FOXC1, which have been demonstrated to be causative for AML. Taken together, our data suggest that WBP5 expression level could serve as an indicator for prognosis and survival outcome in patients with AML.

AB - WW domain binding protein 5 (WBP5), also known as Transcriptional Elongation Factor A like 9 (TCEAL9) has been proposed as a candidate oncogene for human colorectal cancers with microsatellite instability and as a predictive indicator of small cell lung cancers. Furthermore, several independent studies have proposed WBP5, and its association with Wilms Tumor-1 (WT1) expression, as part of a gene expression-based risk score for predicting survival and clinical outcome in patients with Acute Myeloid Leukaemia (AML). To date, the prognostic significance of the sole WBP5 expression and its impact on the survival outcome in AML patients remains largely understudied. In the present study, we have made use of publicly available patient expression arrays and have developed an unbiased approach to classify AML patients into low versus high WBP5 expressers and to balance them for known mutations and cytogenetic findings. Interestingly, we found that patients characterized by high WBP5 expression displayed inferior overall and event-free survival rates. Notably, gene expression profiling showed that patients with high WBP5 had elevated expression of several HOX cluster genes, such as HOXA5, HOXA7, HOXA9 and HOXA10, and several of their partner proteins, such as MEIS1 and FOXC1, which have been demonstrated to be causative for AML. Taken together, our data suggest that WBP5 expression level could serve as an indicator for prognosis and survival outcome in patients with AML.

KW - Biomarkers, Tumor/metabolism

KW - Cluster Analysis

KW - Forkhead Transcription Factors/metabolism

KW - Homeodomain Proteins/genetics

KW - Humans

KW - Kaplan-Meier Estimate

KW - Karyotype

KW - Leukemia, Myeloid, Acute/metabolism

KW - Multigene Family

KW - Myeloid Ecotropic Viral Integration Site 1 Protein/metabolism

KW - Nuclear Proteins/genetics

KW - Prognosis

KW - Progression-Free Survival

KW - Transcriptome

KW - Up-Regulation

UR - http://www.scopus.com/inward/record.url?scp=85080027939&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-60480-x

DO - 10.1038/s41598-020-60480-x

M3 - Article

C2 - 32103106

AN - SCOPUS:85080027939

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3505

ER -