High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

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High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. / Hassan-Smith, G; Durant, L; Tsentemeidou, A; Assi, L K; Faint, J M; Kalra, S; Douglas, M R; Curnow, S J.

In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 175-179.

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@article{c027a3316049455c85d8bab24db9b626,
title = "High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis",
abstract = "Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive — more than OCB testing — and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.",
keywords = "Adult, Aged, Female, Humans, Immunoglobulin kappa-Chains, Male, Middle Aged, Multiple Sclerosis, Nephelometry and Turbidimetry, Oligoclonal Bands, Sensitivity and Specificity, Young Adult",
author = "G Hassan-Smith and L Durant and A Tsentemeidou and Assi, {L K} and Faint, {J M} and S Kalra and Douglas, {M R} and Curnow, {S J}",
year = "2014",
month = "11",
day = "15",
doi = "10.1016/j.jneuroim.2014.08.003",
language = "English",
volume = "276",
pages = "175--179",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

AU - Hassan-Smith, G

AU - Durant, L

AU - Tsentemeidou, A

AU - Assi, L K

AU - Faint, J M

AU - Kalra, S

AU - Douglas, M R

AU - Curnow, S J

PY - 2014/11/15

Y1 - 2014/11/15

N2 - Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive — more than OCB testing — and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.

AB - Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive — more than OCB testing — and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.

KW - Adult

KW - Aged

KW - Female

KW - Humans

KW - Immunoglobulin kappa-Chains

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Nephelometry and Turbidimetry

KW - Oligoclonal Bands

KW - Sensitivity and Specificity

KW - Young Adult

U2 - 10.1016/j.jneuroim.2014.08.003

DO - 10.1016/j.jneuroim.2014.08.003

M3 - Article

C2 - 25146968

VL - 276

SP - 175

EP - 179

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -