High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

Research output: Contribution to journalArticlepeer-review


Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive — more than OCB testing — and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.


Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalJournal of Neuroimmunology
Issue number1-2
Early online date8 Aug 2014
Publication statusPublished - 15 Nov 2014


  • Adult, Aged, Female, Humans, Immunoglobulin kappa-Chains, Male, Middle Aged, Multiple Sclerosis, Nephelometry and Turbidimetry, Oligoclonal Bands, Sensitivity and Specificity, Young Adult