High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

Research output: Contribution to journalArticlepeer-review

Authors

  • Qian Dou
  • Debo Hu
  • Hongkai Gao
  • Yongmei Zhang
  • Jing Wang
  • Guangjun Nie
  • Qing Dai

Colleges, School and Institutes

External organisations

  • Armed Police General Hospital
  • Division of Nanophotonics, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology

Abstract

Rapid and robust hydrogels are essential in realizing continuous glucose monitoring in diabetes monitoring. However, existing hydrogels are limited in satisfying all of the sensory requirements such as detection range, response time, recoverability and biocompatibility. Here, we have developed a surface-initiated polymerization method to chemically immobilize a nano-boronic acid-hydrogel membrane onto a quartz crystal, then used a quartz crystal microbalance (QCM) to achieve real-time monitoring of glucose. The experimental results show that this hydrogel possesses enhanced binding properties to glucose under physiological conditions (pH 7.0-7.5) and blood glucose concentration (BGC) (1.1-33.3 mM). Moreover, our hydrogel displayed a rapid response time (∼100 s) to glucose, high biocompatibility in vivo through an animal model. The hydrogel has a great potential as a sensitive glucose probe for implantable continuous glucose sensors.

Details

Original languageEnglish
Pages (from-to)41384-41390
Number of pages7
JournalRSC Advances
Volume7
Issue number66
Publication statusPublished - 24 Aug 2017

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