High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation

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High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation. / Sadnicka, Anna; Stevenson, Anna; Bhatia, Kailash P.; Rothwell, John C.; Edwards, Mark J.; Galea, Joseph.

In: Scientific Reports, Vol. 8, 3653, 26.02.2018.

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Sadnicka, Anna ; Stevenson, Anna ; Bhatia, Kailash P. ; Rothwell, John C. ; Edwards, Mark J. ; Galea, Joseph. / High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation. In: Scientific Reports. 2018 ; Vol. 8.

Bibtex

@article{d5d85d32c1d5477d9dcf7b5e9a404cf4,
title = "High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation",
abstract = "For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using arobotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any covariance with performance indicators during an error-based learning visuomotor adaptation task. First, weconfirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted.",
keywords = "cerebellum , dystonia , motor control , movement disorders",
author = "Anna Sadnicka and Anna Stevenson and Bhatia, {Kailash P.} and Rothwell, {John C.} and Edwards, {Mark J.} and Joseph Galea",
year = "2018",
month = feb,
day = "26",
doi = "10.1038/s41598-018-21545-0",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation

AU - Sadnicka, Anna

AU - Stevenson, Anna

AU - Bhatia, Kailash P.

AU - Rothwell, John C.

AU - Edwards, Mark J.

AU - Galea, Joseph

PY - 2018/2/26

Y1 - 2018/2/26

N2 - For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using arobotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any covariance with performance indicators during an error-based learning visuomotor adaptation task. First, weconfirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted.

AB - For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using arobotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any covariance with performance indicators during an error-based learning visuomotor adaptation task. First, weconfirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted.

KW - cerebellum

KW - dystonia

KW - motor control

KW - movement disorders

U2 - 10.1038/s41598-018-21545-0

DO - 10.1038/s41598-018-21545-0

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 3653

ER -