High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma

Research output: Contribution to journalArticle

Authors

  • Y Wang
  • R Zhang
  • Y Wu
  • Z Wang
  • Y Zhu
  • D Li
  • Q Ji

Colleges, School and Institutes

Abstract

AIMS: To investigate the frequency and clinical significance of RET rearrangement in Chinese patients with papillary thyroid carcinoma (PTC) and discuss the role of RET rearrangement in therapeutic decision-making after the performance of level VI lymph node dissection and the 2002 AJCC staging system. METHODS: RET/PTC-1 and RET/PTC-3 were detected in 126 PTCs using reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. RESULTS: RET rearrangement was detected in 18 cases of PTC. The patient group aged <20 years had the highest frequency (3/6) of RET rearrangement among the age groups (<20 years, 20-40 years and > or = 40 years; P=0.03). RET/PTC-1 positive patients were more likely to suffer from Hashimoto's thyroiditis simultaneously (P=0.02) while RET/PTC-3 positive patients had a higher frequency of extrathyroidal extension (P

Details

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalEuropean Journal of Surgical Oncology (EJSO)
Volume34
Issue number1
Publication statusPublished - 1 Jan 2008