High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma

Y Wang; R Zhang; Zewei Luo; Y Wu; Xiaofeng Du; Z Wang; Y Zhu; D Li; Q Ji

doi:10.1016/j.ejso.2007.08.012

High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma

Y Wang, R Zhang, Zewei Luo, Y Wu, Xiaofeng Du, Z Wang, Y Zhu, D Li, Q Ji

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Abstract

AIMS: To investigate the frequency and clinical significance of RET rearrangement in Chinese patients with papillary thyroid carcinoma (PTC) and discuss the role of RET rearrangement in therapeutic decision-making after the performance of level VI lymph node dissection and the 2002 AJCC staging system. METHODS: RET/PTC-1 and RET/PTC-3 were detected in 126 PTCs using reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. RESULTS: RET rearrangement was detected in 18 cases of PTC. The patient group aged <20 years had the highest frequency (3/6) of RET rearrangement among the age groups (<20 years, 20-40 years and > or = 40 years; P=0.03). RET/PTC-1 positive patients were more likely to suffer from Hashimoto's thyroiditis simultaneously (P=0.02) while RET/PTC-3 positive patients had a higher frequency of extrathyroidal extension (P

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	European Journal of Surgical Oncology (EJSO)
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.ejso.2007.08.012
Publication status	Published - 1 Jan 2008

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10.1016/j.ejso.2007.08.012

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title = "High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma",

abstract = "AIMS: To investigate the frequency and clinical significance of RET rearrangement in Chinese patients with papillary thyroid carcinoma (PTC) and discuss the role of RET rearrangement in therapeutic decision-making after the performance of level VI lymph node dissection and the 2002 AJCC staging system. METHODS: RET/PTC-1 and RET/PTC-3 were detected in 126 PTCs using reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. RESULTS: RET rearrangement was detected in 18 cases of PTC. The patient group aged <20 years had the highest frequency (3/6) of RET rearrangement among the age groups (<20 years, 20-40 years and > or = 40 years; P=0.03). RET/PTC-1 positive patients were more likely to suffer from Hashimoto's thyroiditis simultaneously (P=0.02) while RET/PTC-3 positive patients had a higher frequency of extrathyroidal extension (P",

author = "Y Wang and R Zhang and Zewei Luo and Y Wu and Xiaofeng Du and Z Wang and Y Zhu and D Li and Q Ji",

year = "2008",

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doi = "10.1016/j.ejso.2007.08.012",

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TY - JOUR

T1 - High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma

AU - Wang, Y

AU - Zhang, R

AU - Luo, Zewei

AU - Wu, Y

AU - Du, Xiaofeng

AU - Wang, Z

AU - Zhu, Y

AU - Li, D

AU - Ji, Q

PY - 2008/1/1

Y1 - 2008/1/1

N2 - AIMS: To investigate the frequency and clinical significance of RET rearrangement in Chinese patients with papillary thyroid carcinoma (PTC) and discuss the role of RET rearrangement in therapeutic decision-making after the performance of level VI lymph node dissection and the 2002 AJCC staging system. METHODS: RET/PTC-1 and RET/PTC-3 were detected in 126 PTCs using reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. RESULTS: RET rearrangement was detected in 18 cases of PTC. The patient group aged <20 years had the highest frequency (3/6) of RET rearrangement among the age groups (<20 years, 20-40 years and > or = 40 years; P=0.03). RET/PTC-1 positive patients were more likely to suffer from Hashimoto's thyroiditis simultaneously (P=0.02) while RET/PTC-3 positive patients had a higher frequency of extrathyroidal extension (P

AB - AIMS: To investigate the frequency and clinical significance of RET rearrangement in Chinese patients with papillary thyroid carcinoma (PTC) and discuss the role of RET rearrangement in therapeutic decision-making after the performance of level VI lymph node dissection and the 2002 AJCC staging system. METHODS: RET/PTC-1 and RET/PTC-3 were detected in 126 PTCs using reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. RESULTS: RET rearrangement was detected in 18 cases of PTC. The patient group aged <20 years had the highest frequency (3/6) of RET rearrangement among the age groups (<20 years, 20-40 years and > or = 40 years; P=0.03). RET/PTC-1 positive patients were more likely to suffer from Hashimoto's thyroiditis simultaneously (P=0.02) while RET/PTC-3 positive patients had a higher frequency of extrathyroidal extension (P

U2 - 10.1016/j.ejso.2007.08.012

DO - 10.1016/j.ejso.2007.08.012

M3 - Article

C2 - 17954023

SN - 1532-2157

VL - 34

SP - 77

EP - 81

JO - European Journal of Surgical Oncology (EJSO)

JF - European Journal of Surgical Oncology (EJSO)

IS - 1

ER -

High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma

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