Projects per year
Abstract
. Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus of the family Flaviviridae that primarily infects hepatocytes, causing acute and chronic liver disease. HCV is also associated with a variety of extrahepatic symptoms including central nervous system (CNS) abnormalities, cognitive dysfunction, fatigue and depression. These symptoms do not correlate with the severity of liver disease and are independent of hepatic encephalopathy. HCV RNA has been associated with CNS tissue, and reports of viral sequence diversity between brain and liver tissue suggest independent viral evolution in the CNS and liver. This review will explore the data supporting HCV infection of the CNS and how this fits into our current understanding of HCV pathogenesis.
Original language | English |
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Pages (from-to) | 301-306 |
Number of pages | 6 |
Journal | Journal of viral hepatitis |
Volume | 19 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2012 |
Keywords
- reservoir
- blood-brain barrier
- human immunodeficiency virus
- central nervous system
- hepatitis C
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Dive into the research topics of 'Hepatitis C virus and the brain'. Together they form a unique fingerprint.Projects
- 2 Finished
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The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis
McKeating, J.
1/01/12 → 30/06/17
Project: Research Councils
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Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury
McKeating, J. & Balfe, P.
1/10/09 → 30/09/12
Project: Research Councils