Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor

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Abstract

MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).

Details

Original languageEnglish
Pages (from-to)815-6
Number of pages2
JournalDevelopmental Cell
Volume14
Issue number6
Publication statusPublished - 1 Jun 2008