Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

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Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU. / Feng, Yu; Wei, Li; Zhu, Shichao; Qiao, Fu; Zhang, Xiaoxia; Kang, Yan; Cai, Lin; Kang, Mei; McNally, Alan; Zong, Zhiyong.

In: The Journal of hospital infection, 10.10.2019.

Research output: Contribution to journalArticle

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Feng, Yu ; Wei, Li ; Zhu, Shichao ; Qiao, Fu ; Zhang, Xiaoxia ; Kang, Yan ; Cai, Lin ; Kang, Mei ; McNally, Alan ; Zong, Zhiyong. / Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU. In: The Journal of hospital infection. 2019.

Bibtex

@article{6e5f47c6afef4a2497690c274b2c4802,
title = "Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU",
abstract = "Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission. ",
keywords = "sinks, carbapenemases, carbapenem resistance, Klebsiella pneumoniae",
author = "Yu Feng and Li Wei and Shichao Zhu and Fu Qiao and Xiaoxia Zhang and Yan Kang and Lin Cai and Mei Kang and Alan McNally and Zhiyong Zong",
note = "Copyright {\textcopyright} 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.",
year = "2019",
month = oct,
day = "10",
doi = "10.1016/j.jhin.2019.10.006",
language = "English",
journal = "The Journal of hospital infection",
issn = "0195-6701",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

AU - Feng, Yu

AU - Wei, Li

AU - Zhu, Shichao

AU - Qiao, Fu

AU - Zhang, Xiaoxia

AU - Kang, Yan

AU - Cai, Lin

AU - Kang, Mei

AU - McNally, Alan

AU - Zong, Zhiyong

N1 - Copyright © 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

PY - 2019/10/10

Y1 - 2019/10/10

N2 - Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission.

AB - Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission.

KW - sinks

KW - carbapenemases

KW - carbapenem resistance

KW - Klebsiella pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=85075895913&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2019.10.006

DO - 10.1016/j.jhin.2019.10.006

M3 - Article

C2 - 31606433

JO - The Journal of hospital infection

JF - The Journal of hospital infection

SN - 0195-6701

ER -