Haemophagocytic lymphohistiocytosis associated with 2 cases of pediatric lymphocyte-depleted classic Hodgkin lymphoma

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Colleges, School and Institutes

External organisations

  • Birmingham Children's Hospital, Steelhouse Lane, Birmingham, United Kingdom.


Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal syndrome of abnormal T-cell activation and cytokine production, which can be familial or secondary in nature. Although HLH can occur concomitantly with lymphomas, the development of HLH alongside Hodgkin lymphoma in children is unusual. Here we report the diagnostic evaluation and clinical course of 2 pediatric cases of HLH secondary to lymphocyte-depleted classic Hodgkin lymphoma. These cases highlight the need to be vigilant for this rare presentation and the difficulties in managing these patients.


Original languageEnglish
JournalJournal of pediatric hematology/oncology
Early online date27 Dec 2018
Publication statusE-pub ahead of print - 27 Dec 2018


  • HLH, Hodgkin, pediatric