Haematological and biochemical reference values of Gambian infants

Aderonke A Odutola; Muhammed O Afolabi; James Jafali; Ignatius Baldeh; Olumuyiwa A Owolabi; Patrick Owiafe; Gibril Bah; Boto Jaiteh; Nuredin I Mohammed; Simon A Donkor; Jorjoh Ndure; Jane Adetifa; Katie L Flanagan; Martin O C Ota

doi:10.1111/tmi.12245

Haematological and biochemical reference values of Gambian infants

Aderonke A Odutola, Muhammed O Afolabi, James Jafali, Ignatius Baldeh, Olumuyiwa A Owolabi, Patrick Owiafe, Gibril Bah, Boto Jaiteh, Nuredin I Mohammed, Simon A Donkor, Jorjoh Ndure, Jane Adetifa, Katie L Flanagan, Martin O C Ota

Applied Health Research

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

OBJECTIVE: To establish haematological and biological reference values for Gambian infants.

METHODS: Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated.

RESULTS: Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count (WBC) and platelet levels decreased with age (P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age (P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age (P = 0.002; P < 0.001, respectively).

CONCLUSION: Our set of haematological and biochemical reference values for healthy infants in The Gambia differs from values in other settings, thus underscoring the importance of establishing region-specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.

Original language	English
Pages (from-to)	275-283
Number of pages	9
Journal	Tropical Medicine & International Health
Volume	19
Issue number	3
Early online date	7 Jan 2014
DOIs	https://doi.org/10.1111/tmi.12245
Publication status	Published - 1 Mar 2014

Keywords

African Continental Ancestry Group
Age Distribution
Alkaline Phosphatase
Body Height
Body Weight
Child Development
Creatinine
Female
Gambia
Hematologic Tests
Hemoglobins
Humans
Infant
Linear Models
Male
Malnutrition
Nutritional Status
Potassium
Reference Values
Sex Distribution
Statistics as Topic
Urban Population
Urea
haematological
biochemical
Gambian infants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1111/tmi.12245Licence: None: All rights reserved

Cite this

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title = "Haematological and biochemical reference values of Gambian infants",

abstract = "OBJECTIVE: To establish haematological and biological reference values for Gambian infants.METHODS: Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated.RESULTS: Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count (WBC) and platelet levels decreased with age (P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age (P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age (P = 0.002; P < 0.001, respectively).CONCLUSION: Our set of haematological and biochemical reference values for healthy infants in The Gambia differs from values in other settings, thus underscoring the importance of establishing region-specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.",

keywords = "African Continental Ancestry Group, Age Distribution, Alkaline Phosphatase, Body Height, Body Weight, Child Development, Creatinine, Female, Gambia, Hematologic Tests, Hemoglobins, Humans, Infant, Linear Models, Male, Malnutrition, Nutritional Status, Potassium, Reference Values, Sex Distribution, Statistics as Topic, Urban Population, Urea, haematological, biochemical, Gambian infants",

author = "Odutola, {Aderonke A} and Afolabi, {Muhammed O} and James Jafali and Ignatius Baldeh and Owolabi, {Olumuyiwa A} and Patrick Owiafe and Gibril Bah and Boto Jaiteh and Mohammed, {Nuredin I} and Donkor, {Simon A} and Jorjoh Ndure and Jane Adetifa and Flanagan, {Katie L} and Ota, {Martin O C}",

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doi = "10.1111/tmi.12245",

language = "English",

volume = "19",

pages = "275--283",

journal = "Tropical Medicine & International Health",

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TY - JOUR

T1 - Haematological and biochemical reference values of Gambian infants

AU - Odutola, Aderonke A

AU - Afolabi, Muhammed O

AU - Jafali, James

AU - Baldeh, Ignatius

AU - Owolabi, Olumuyiwa A

AU - Owiafe, Patrick

AU - Bah, Gibril

AU - Jaiteh, Boto

AU - Mohammed, Nuredin I

AU - Donkor, Simon A

AU - Ndure, Jorjoh

AU - Adetifa, Jane

AU - Flanagan, Katie L

AU - Ota, Martin O C

PY - 2014/3/1

Y1 - 2014/3/1

N2 - OBJECTIVE: To establish haematological and biological reference values for Gambian infants.METHODS: Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated.RESULTS: Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count (WBC) and platelet levels decreased with age (P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age (P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age (P = 0.002; P < 0.001, respectively).CONCLUSION: Our set of haematological and biochemical reference values for healthy infants in The Gambia differs from values in other settings, thus underscoring the importance of establishing region-specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.

AB - OBJECTIVE: To establish haematological and biological reference values for Gambian infants.METHODS: Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated.RESULTS: Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count (WBC) and platelet levels decreased with age (P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age (P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age (P = 0.002; P < 0.001, respectively).CONCLUSION: Our set of haematological and biochemical reference values for healthy infants in The Gambia differs from values in other settings, thus underscoring the importance of establishing region-specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.

KW - African Continental Ancestry Group

KW - Age Distribution

KW - Alkaline Phosphatase

KW - Body Height

KW - Body Weight

KW - Child Development

KW - Creatinine

KW - Female

KW - Gambia

KW - Hematologic Tests

KW - Hemoglobins

KW - Humans

KW - Infant

KW - Linear Models

KW - Male

KW - Malnutrition

KW - Nutritional Status

KW - Potassium

KW - Reference Values

KW - Sex Distribution

KW - Statistics as Topic

KW - Urban Population

KW - Urea

KW - haematological

KW - biochemical

KW - Gambian infants

U2 - 10.1111/tmi.12245

DO - 10.1111/tmi.12245

M3 - Article

C2 - 24393095

SN - 1360-2276

VL - 19

SP - 275

EP - 283

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

IS - 3

ER -

Haematological and biochemical reference values of Gambian infants

Abstract

Keywords

UN SDGs

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