TY - JOUR
T1 - Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions:
T2 - A position paper
AU - Thut, Gregor
AU - Bergmann, Til Ole
AU - Fröhlich, Flavio
AU - Soekadar, Surjo R.
AU - Brittain, John-Stuart
AU - Valero-Cabré, Antoni
AU - Sack, Alexander T.
AU - Miniussi, Carlo
AU - Antal, Andrea
AU - Siebner, Hartwig Roman
AU - Ziemann, Ulf
AU - Herrmann, Christoph S.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Non-invasive transcranial brain stimulation (NTBS) techniques have a wide range of applications but also suffer from a number of limitations mainly related to poor specificity of intervention and variable effect size. These limitations motivated recent efforts to focus on the temporal dimension of NTBS with respect to the ongoing brain activity. Temporal patterns of ongoing neuronal activity, in particular brain oscillations and their fluctuations, can be traced with electro- or magnetoencephalography (EEG/MEG), to guide the timing as well as the stimulation settings of NTBS. These novel, online and offline EEG/MEG-guided NTBS-approaches are tailored to specifically interact with the underlying brain activity. Online EEG/MEG has been used to guide the timing of NTBS (i.e., when to stimulate): by taking into account instantaneous phase or power of oscillatory brain activity, NTBS can be aligned to fluctuations in excitability states. Moreover, offline EEG/MEG recordings prior to interventions can inform researchers and clinicians how to stimulate: by frequency-tuning NTBS to the oscillation of interest, intrinsic brain oscillations can be up- or down-regulated. In this paper, we provide an overview of existing approaches and ideas of EEG/MEG-guided interventions, and their promises and caveats. We point out potential future lines of research to address challenges.
AB - Non-invasive transcranial brain stimulation (NTBS) techniques have a wide range of applications but also suffer from a number of limitations mainly related to poor specificity of intervention and variable effect size. These limitations motivated recent efforts to focus on the temporal dimension of NTBS with respect to the ongoing brain activity. Temporal patterns of ongoing neuronal activity, in particular brain oscillations and their fluctuations, can be traced with electro- or magnetoencephalography (EEG/MEG), to guide the timing as well as the stimulation settings of NTBS. These novel, online and offline EEG/MEG-guided NTBS-approaches are tailored to specifically interact with the underlying brain activity. Online EEG/MEG has been used to guide the timing of NTBS (i.e., when to stimulate): by taking into account instantaneous phase or power of oscillatory brain activity, NTBS can be aligned to fluctuations in excitability states. Moreover, offline EEG/MEG recordings prior to interventions can inform researchers and clinicians how to stimulate: by frequency-tuning NTBS to the oscillation of interest, intrinsic brain oscillations can be up- or down-regulated. In this paper, we provide an overview of existing approaches and ideas of EEG/MEG-guided interventions, and their promises and caveats. We point out potential future lines of research to address challenges.
KW - non-invasive transcranial brain simulators (NTBS)
KW - electroencephalography
KW - magnetoencephalography
KW - brain oscillations
KW - temporally guided NTBS
U2 - 10.1016/j.clinph.2017.01.003
DO - 10.1016/j.clinph.2017.01.003
M3 - Article
SN - 1388-2457
VL - 128
SP - 843
EP - 857
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 5
ER -