Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study

Research output: Contribution to journalArticlepeer-review


  • Thomas Villemonteix
  • Hichem Slama
  • Martin Kavec
  • Danielle Balériaux
  • Thierry Metens
  • Simon Baijot
  • Alison Mary
  • Philippe Peigneux
  • Isabelle Massat

Colleges, School and Institutes


Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD.

Bibliographic note

Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.


Original languageEnglish
Pages (from-to)32-7
Number of pages6
JournalDevelopmental Cognitive Neuroscience
Early online date11 Jun 2015
Publication statusPublished - Aug 2015


  • Attention deficit/hyperactivity disorder (ADHD), Anterior cingulate cortex, Gender, MRI, Emotion regulation