@article{46462218e0ef4b67877e7e6094b44bb0,
title = "Gold(I)-catalyzed synthesis of 3-sulfenyl pyrroles and indoles by a regioselective annulation of alkynyl thioethers",
abstract = "The combination of nucleophilic nitrenoids and π-acid catalysis has emerged as a powerful tool in heterocycle synthesis. Accessing more varied heterocycle-substitution patterns by maintaining the same reaction pathways across different alkynes remains a challenge. Here we show that Au(I) catalysis of isoxazole-based nitrenoids with alkynyl thioethers provides controlled access to (3 + 2) annulation by a regioselective addition β to the sulfenyl group. The reaction with isoxazole-containing nitrenoids delivers sulfenylated pyrroles and indoles as single regioisomers bearing useful functional groups and structural variety.",
keywords = "annulation, gold, indole, nitrenoid, pyrroles, thioether",
author = "Peter Simm and Prakash Sekar and Jeffery Richardson and Paul Davies",
note = "Funding Information: We thank the EPSRC and Eli Lilly for funding (NPIF studentship EP/R512436/1, P.E.S.). This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No. 839037 (P.S., SEAROX). P.W.D. is grateful to the Royal Society and Leverhulme Trust for the award of a Senior Research Fellowship (SRF\R1\191033). The authors gratefully acknowledge support from Dr. Louise Male (XRD) and the Centre for Chemical and Materials Analysis in the School of Chemistry (UoB). Publisher Copyright: {\textcopyright} 2021 The Authors. Published by American Chemical Society.",
year = "2021",
month = jun,
day = "4",
doi = "10.1021/acscatal.1c01457",
language = "English",
volume = "11",
pages = "6357–6362",
journal = "ACS Catalysis",
issn = "2155-5435",
publisher = "American Chemical Society",
number = "11",
}