Research output per year
Research output per year
Paige Rist, Richard Grainger, Paul Davies
Research output: Contribution to journal › Article › peer-review
C3-selective C-C bond formation on benzothiophenes is challenging, and few direct functionalization methods are available. A gold-catalyzed reaction of alkynes with benzothiophene S-oxides provides regioselective entry into C3-alkylated benzothiophenes with the C7-alkylated isomer as the minor product. This oxyarylation reaction works with alkyl and aryl alkynes and substituted and unsubstituted benzothiophenes. Mechanistic studies identify that sulfoxide inhibits the catalyst [DTBPAu(PhCN)]SbF6, which also degrades and forms the unreactive complex [(DTBP)2Au]SbF6.
Original language | English |
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Pages (from-to) | 642–646 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 23 |
Issue number | 3 |
Early online date | 19 Jan 2021 |
DOIs | |
Publication status | Published - 5 Feb 2021 |
Research output: Contribution to journal › Article › peer-review
28/01/20 → 27/07/21
Project: Research Councils
Rist, P. (Creator), Grainger, R. (Supervisor) & Davies, P. (Supervisor), University of Birmingham, 14 Jan 2021
DOI: https://doi.org/10.25500/edata.bham.00000583
Dataset
Facility/equipment: Equipment