Gold-catalyzed intermolecular alkyne oxyarylation for C3-functionalization of benzothiophenes
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
C3-selective C-C bond formation on benzothiophenes is challenging, and few direct functionalization methods are available. A gold-catalyzed reaction of alkynes with benzothiophene S-oxides provides regioselective entry into C3-alkylated benzothiophenes with the C7-alkylated isomer as the minor product. This oxyarylation reaction works with alkyl and aryl alkynes and substituted and unsubstituted benzothiophenes. Mechanistic studies identify that sulfoxide inhibits the catalyst [DTBPAu(PhCN)]SbF6, which also degrades and forms the unreactive complex [(DTBP)2Au]SbF6.
|Number of pages||5|
|Early online date||19 Jan 2021|
|Publication status||Published - 5 Feb 2021|