Gold-catalysed cycloisomerisation of ynamides to access 2,2-disubstituted tetrahydrothiophene motifs
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Ynamides bearing a tethered allyl sulfoxide undergo a gold-catalysed cycloisomerisation to afford 2-carboxylic amide tetrahydrothiophenes and their benzofused analogues. The reactions are initiated by a formal 7-endo-dig cyclisation and accommodate a range of different substituents. The use of N-allyl ynamides provided a route into novel spirocyclic ε-lactam structures.
Funding Information: We thank the EPSRC for funding (EP/F031254/1).
|Early online date||13 Mar 2021|
|Publication status||E-pub ahead of print - 13 Mar 2021|