Gold-catalysed cycloisomerisation of ynamides to access 2,2-disubstituted tetrahydrothiophene motifs

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

Abstract

Ynamides bearing a tethered allyl sulfoxide undergo a gold-catalysed cycloisomerisation to afford 2-carboxylic amide tetrahydrothiophenes and their benzofused analogues. The reactions are initiated by a formal 7-endo-dig cyclisation and accommodate a range of different substituents. The use of N-allyl ynamides provided a route into novel spirocyclic ε-lactam structures.

Bibliographic note

Funding Information: We thank the EPSRC for funding (EP/F031254/1).

Details

Original languageEnglish
Pages (from-to)1-4
JournalSynlett
Volume2021
Issue number00
Early online date13 Mar 2021
Publication statusE-pub ahead of print - 13 Mar 2021