Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

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Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo. / Legrand, Catherine; Ahmed, Usman ; Anwar, Attia; Rajpoot, Kashif; Pasha, Sabah; Lambert, Cécile; Davidson, Rose K.; Clark, Ian M.; Thornalley, Paul J.; Henrotin, Yves; Rabbani, Naila.

In: Arthritis Research & Therapy, Vol. 20, 131, 22.06.2018.

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Legrand, Catherine ; Ahmed, Usman ; Anwar, Attia ; Rajpoot, Kashif ; Pasha, Sabah ; Lambert, Cécile ; Davidson, Rose K. ; Clark, Ian M. ; Thornalley, Paul J. ; Henrotin, Yves ; Rabbani, Naila. / Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo. In: Arthritis Research & Therapy. 2018 ; Vol. 20.

Bibtex

@article{ddbc33a352b446d4b66012c226b6651d,
title = "Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo",
abstract = "Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown. We studied this in an OA animal model as well as interleukin-1β-activated human chondrocytes in vitro and translated key findings to patients with OA.",
keywords = "Glycation, Oxidative Stress, Citrullination, Inflammation, Machine Learning",
author = "Catherine Legrand and Usman Ahmed and Attia Anwar and Kashif Rajpoot and Sabah Pasha and C{\'e}cile Lambert and Davidson, {Rose K.} and Clark, {Ian M.} and Thornalley, {Paul J.} and Yves Henrotin and Naila Rabbani",
year = "2018",
month = jun
day = "22",
doi = "10.1186/s13075-018-1636-6",
language = "English",
volume = "20",
journal = "Arthritis Research & Therapy",
issn = "1478-6354",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

AU - Legrand, Catherine

AU - Ahmed, Usman

AU - Anwar, Attia

AU - Rajpoot, Kashif

AU - Pasha, Sabah

AU - Lambert, Cécile

AU - Davidson, Rose K.

AU - Clark, Ian M.

AU - Thornalley, Paul J.

AU - Henrotin, Yves

AU - Rabbani, Naila

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown. We studied this in an OA animal model as well as interleukin-1β-activated human chondrocytes in vitro and translated key findings to patients with OA.

AB - Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown. We studied this in an OA animal model as well as interleukin-1β-activated human chondrocytes in vitro and translated key findings to patients with OA.

KW - Glycation

KW - Oxidative Stress

KW - Citrullination

KW - Inflammation

KW - Machine Learning

U2 - 10.1186/s13075-018-1636-6

DO - 10.1186/s13075-018-1636-6

M3 - Article

VL - 20

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

SN - 1478-6354

M1 - 131

ER -