Glucose sensing via aggregation and the use of "knock-out" binding to improve selectivity

Yan-Jun Huang; Wen-Juan Ouyang; Xin Wu; Zhao Li; John S Fossey; Tony D James; Yun-Bao Jiang

doi:10.1021/ja311442x

Glucose sensing via aggregation and the use of "knock-out" binding to improve selectivity

Yan-Jun Huang, Wen-Juan Ouyang, Xin Wu, Zhao Li, John S Fossey, Tony D James, Yun-Bao Jiang

Chemistry

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by "knock-out" binding of fructose by phenylboronic acid.

Original language	English
Pages (from-to)	1700-1703
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	5
DOIs	https://doi.org/10.1021/ja311442x
Publication status	Published - 6 Feb 2013

Keywords

Binding Sites
Boronic Acids
Fluorescent Dyes
Fructose
Glucose
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Molecular Structure
Pyrenes
Spectrometry, Fluorescence
Substrate Specificity

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10.1021/ja311442x

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abstract = "Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by {"}knock-out{"} binding of fructose by phenylboronic acid.",

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AU - Huang, Yan-Jun

AU - Ouyang, Wen-Juan

AU - Wu, Xin

AU - Li, Zhao

AU - Fossey, John S

AU - James, Tony D

AU - Jiang, Yun-Bao

PY - 2013/2/6

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N2 - Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by "knock-out" binding of fructose by phenylboronic acid.

AB - Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by "knock-out" binding of fructose by phenylboronic acid.

KW - Binding Sites

KW - Boronic Acids

KW - Fluorescent Dyes

KW - Fructose

KW - Glucose

KW - Hydrophobic and Hydrophilic Interactions

KW - Models, Molecular

KW - Molecular Structure

KW - Pyrenes

KW - Spectrometry, Fluorescence

KW - Substrate Specificity

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DO - 10.1021/ja311442x

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EP - 1703

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 5

ER -

Glucose sensing via aggregation and the use of "knock-out" binding to improve selectivity

Abstract

Keywords

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