Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies

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Glucocorticoid dynamics : insights from mathematical, experimental and clinical studies. / Spiga, F.; Walker, J.J.; Gupta, R.; Terry, J.R.; Lightman, S.L.

In: Journal of Endocrinology, Vol. 226, No. 2, 08.2015, p. T55-T66.

Research output: Contribution to journalReview articlepeer-review

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Spiga, F. ; Walker, J.J. ; Gupta, R. ; Terry, J.R. ; Lightman, S.L. / Glucocorticoid dynamics : insights from mathematical, experimental and clinical studies. In: Journal of Endocrinology. 2015 ; Vol. 226, No. 2. pp. T55-T66.

Bibtex

@article{bb5188f6e023430e804538dafd517bba,
title = "Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies",
abstract = "A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic–pituitary–adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review we discuss the mechanisms regulating pulsatile dynamics of the HPA axis, and how these dynamics become disrupted in disease. Our recent mathematical, experimental and clinical studies show that glucocorticoid pulsatility can be generated and maintained by dynamic processes at the level of the pituitary–adrenal axis, and that an intra-adrenal negative feedback may contribute to these dynamics.",
keywords = "HPA axis, ultradian rhythms, glucocorticoids, adrenal cortex",
author = "F. Spiga and J.J. Walker and R. Gupta and J.R. Terry and S.L. Lightman",
year = "2015",
month = aug,
doi = "10.1530/JOE-15-0132",
language = "English",
volume = "226",
pages = "T55--T66",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica",
number = "2",

}

RIS

TY - JOUR

T1 - Glucocorticoid dynamics

T2 - insights from mathematical, experimental and clinical studies

AU - Spiga, F.

AU - Walker, J.J.

AU - Gupta, R.

AU - Terry, J.R.

AU - Lightman, S.L.

PY - 2015/8

Y1 - 2015/8

N2 - A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic–pituitary–adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review we discuss the mechanisms regulating pulsatile dynamics of the HPA axis, and how these dynamics become disrupted in disease. Our recent mathematical, experimental and clinical studies show that glucocorticoid pulsatility can be generated and maintained by dynamic processes at the level of the pituitary–adrenal axis, and that an intra-adrenal negative feedback may contribute to these dynamics.

AB - A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic–pituitary–adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review we discuss the mechanisms regulating pulsatile dynamics of the HPA axis, and how these dynamics become disrupted in disease. Our recent mathematical, experimental and clinical studies show that glucocorticoid pulsatility can be generated and maintained by dynamic processes at the level of the pituitary–adrenal axis, and that an intra-adrenal negative feedback may contribute to these dynamics.

KW - HPA axis

KW - ultradian rhythms

KW - glucocorticoids

KW - adrenal cortex

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84942693627&partnerID=MN8TOARS

U2 - 10.1530/JOE-15-0132

DO - 10.1530/JOE-15-0132

M3 - Review article

VL - 226

SP - T55-T66

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

IS - 2

ER -