Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype
Research output: Contribution to journal › Review article › peer-review
- Public Health England, West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham B5 9SS, UK.
- Magus Strategic Communications Ltd
Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27. Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.
|Number of pages||11|
|Journal||Journal of Antimicrobial Chemotherapy|
|Early online date||25 May 2017|
|Publication status||Published - 1 Aug 2017|
- Animals, Disease Transmission, Infectious, Enterobacteriaceae/enzymology, Enterobacteriaceae Infections/epidemiology, Gene Transfer, Horizontal, Genotype, Global Health, Humans, Molecular Epidemiology, Phylogeography, Spatio-Temporal Analysis, beta-Lactamases/genetics