Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast

Mirvat El-Sibai; Daniel E. Platt; Marc Haber; Yali Xue; Sonia C. Youhanna; R. Spencer Wells; Hassan Izaabel; May F. Sanyoura; Haidar Harmanani; Maziar Ashrafian Bonab; Jaafar Behbehani; Fuad Hashwa; Chris Tyler-Smith; Pierre A. Zalloua

doi:10.1111/j.1469-1809.2009.00538.x

Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast

Mirvat El-Sibai, Daniel E. Platt, Marc Haber, Yali Xue, Sonia C. Youhanna, R. Spencer Wells, Hassan Izaabel, May F. Sanyoura, Haidar Harmanani, Maziar Ashrafian Bonab, Jaafar Behbehani, Fuad Hashwa, Chris Tyler-Smith, Pierre A. Zalloua^*

^*Corresponding author for this work

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.

Original language	English
Pages (from-to)	568-581
Number of pages	14
Journal	Annals of Human Genetics
Volume	73
Issue number	6
DOIs	https://doi.org/10.1111/j.1469-1809.2009.00538.x
Publication status	Published - Nov 2009

Keywords

Levant
Y chromosome
Y-SNP
Y-STR

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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El-Sibai, M., Platt, D. E., Haber, M., Xue, Y., Youhanna, S. C., Wells, R. S., Izaabel, H., Sanyoura, M. F., Harmanani, H., Bonab, M. A., Behbehani, J., Hashwa, F., Tyler-Smith, C., & Zalloua, P. A. (2009). Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast. Annals of Human Genetics, 73(6), 568-581. https://doi.org/10.1111/j.1469-1809.2009.00538.x

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title = "Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast",

abstract = "We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.",

keywords = "Levant, Y chromosome, Y-SNP, Y-STR",

author = "Mirvat El-Sibai and Platt, {Daniel E.} and Marc Haber and Yali Xue and Youhanna, {Sonia C.} and Wells, {R. Spencer} and Hassan Izaabel and Sanyoura, {May F.} and Haidar Harmanani and Bonab, {Maziar Ashrafian} and Jaafar Behbehani and Fuad Hashwa and Chris Tyler-Smith and Zalloua, {Pierre A.}",

year = "2009",

month = nov,

doi = "10.1111/j.1469-1809.2009.00538.x",

language = "English",

volume = "73",

pages = "568--581",

journal = "Annals of Human Genetics",

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El-Sibai, M, Platt, DE, Haber, M, Xue, Y, Youhanna, SC, Wells, RS, Izaabel, H, Sanyoura, MF, Harmanani, H, Bonab, MA, Behbehani, J, Hashwa, F, Tyler-Smith, C & Zalloua, PA 2009, 'Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast', Annals of Human Genetics, vol. 73, no. 6, pp. 568-581. https://doi.org/10.1111/j.1469-1809.2009.00538.x

TY - JOUR

T1 - Geographical structure of the Y-chromosomal genetic landscape of the levant

T2 - A coastal-inland contrast

AU - El-Sibai, Mirvat

AU - Platt, Daniel E.

AU - Haber, Marc

AU - Xue, Yali

AU - Youhanna, Sonia C.

AU - Wells, R. Spencer

AU - Izaabel, Hassan

AU - Sanyoura, May F.

AU - Harmanani, Haidar

AU - Bonab, Maziar Ashrafian

AU - Behbehani, Jaafar

AU - Hashwa, Fuad

AU - Tyler-Smith, Chris

AU - Zalloua, Pierre A.

PY - 2009/11

Y1 - 2009/11

N2 - We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.

AB - We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.

KW - Levant

KW - Y chromosome

KW - Y-SNP

KW - Y-STR

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SN - 0003-4800

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JO - Annals of Human Genetics

JF - Annals of Human Genetics

IS - 6

ER -

Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast

Abstract

Keywords

ASJC Scopus subject areas

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