Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials

Hesham Mehanna; Natalie Franklin; Natalie Compton; Max Robinson; Ned Powell; Nigel Biswas-Baldwin; Vinidh Paleri; Andrew Hartley; Lydia  Fresco; Hoda Hoda Al-Booz; Liz Junor; Iman El-Hariry; Sally Roberts; Kevin Harrington; Kie-Kian Ang; Janet Dunn; Ciaran Woodman

doi:10.1002/hed.24336

Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials

Hesham Mehanna, Natalie Franklin, Natalie Compton, Max Robinson, Ned Powell, Nigel Biswas-Baldwin, Vinidh Paleri, Andrew Hartley, Lydia Fresco, Hoda Hoda Al-Booz, Liz Junor, Iman El-Hariry, Sally Roberts, Kevin Harrington, Kie-Kian Ang, Janet Dunn, Ciaran Woodman

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Abstract

Background: There are variations in the proportions of head and neck cancers (HNC) caused by the Human Papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.Methods: We tested FFPE diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by PCR and ISH) using validated protocols on samples from 801 HNC patients recruited prospectively between 2006 – 2011 in 4 RCTs. Results: 21% (170/801) showed both HPV-DNA and p16 positivity, detected almost exclusively in oropharyngeal cancer (OPC) (55%, 15/302); only 1%, (5/499) non-OPC were positive. HPV OPC differed between Western and Eastern Europe (37%, 155/422vs 6%, 8/144 p<0.0001) and between Western Europe and Asia (37% vs 2%, 4/217, p<0·0001). Other independent determinants of HPV positivity were tumour site and smoking. Conclusions: This is the first study to establish geographic variability as an independent risk factor in HPV OPC prevalence, with higher prevalence in Western Europe.

Original language	English
Pages (from-to)	E1863–E1869
Journal	Head & Neck
Volume	38
Issue number	S1
Early online date	8 Jan 2016
DOIs	https://doi.org/10.1002/hed.24336
Publication status	Published - 25 Apr 2016

Keywords

Oropharnx
Head
Neck
Cancer
squamous
cell
carcinom
human
Papillomavirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mehanna_et_al_Geographic_variation_in_human_Head_&_Neck_2016
© 2016 Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 218 KBLicence: Creative Commons: Attribution (CC BY)

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Mehanna, H., Franklin, N., Compton, N., Robinson, M., Powell, N., Biswas-Baldwin, N., Paleri, V., Hartley, A., Fresco, L., Hoda Al-Booz, H., Junor, L., El-Hariry, I., Roberts, S., Harrington, K., Ang, K-K., Dunn, J., & Woodman, C. (2016). Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials. Head & Neck, 38(S1), E1863–E1869. Advance online publication. https://doi.org/10.1002/hed.24336

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title = "Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials",

abstract = "Background: There are variations in the proportions of head and neck cancers (HNC) caused by the Human Papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.Methods: We tested FFPE diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by PCR and ISH) using validated protocols on samples from 801 HNC patients recruited prospectively between 2006 – 2011 in 4 RCTs. Results: 21% (170/801) showed both HPV-DNA and p16 positivity, detected almost exclusively in oropharyngeal cancer (OPC) (55%, 15/302); only 1%, (5/499) non-OPC were positive. HPV OPC differed between Western and Eastern Europe (37%, 155/422vs 6%, 8/144 p<0.0001) and between Western Europe and Asia (37% vs 2%, 4/217, p<0·0001). Other independent determinants of HPV positivity were tumour site and smoking. Conclusions: This is the first study to establish geographic variability as an independent risk factor in HPV OPC prevalence, with higher prevalence in Western Europe. ",

keywords = "Oropharnx, Head, Neck, Cancer, squamous, cell , carcinom, human, Papillomavirus",

author = "Hesham Mehanna and Natalie Franklin and Natalie Compton and Max Robinson and Ned Powell and Nigel Biswas-Baldwin and Vinidh Paleri and Andrew Hartley and Lydia Fresco and {Hoda Al-Booz}, Hoda and Liz Junor and Iman El-Hariry and Sally Roberts and Kevin Harrington and Kie-Kian Ang and Janet Dunn and Ciaran Woodman",

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month = apr,

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doi = "10.1002/hed.24336",

language = "English",

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journal = "Head & Neck",

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Mehanna, H, Franklin, N, Compton, N, Robinson, M, Powell, N, Biswas-Baldwin, N, Paleri, V, Hartley, A, Fresco, L, Hoda Al-Booz, H, Junor, L, El-Hariry, I, Roberts, S, Harrington, K, Ang, K-K, Dunn, J & Woodman, C 2016, 'Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials', Head & Neck, vol. 38, no. S1, pp. E1863–E1869. https://doi.org/10.1002/hed.24336

TY - JOUR

T1 - Geographic variation in human papillomavirus–related oropharyngeal cancer

T2 - data from four multinational randomized trials

AU - Mehanna, Hesham

AU - Franklin, Natalie

AU - Compton, Natalie

AU - Robinson, Max

AU - Powell, Ned

AU - Biswas-Baldwin, Nigel

AU - Paleri, Vinidh

AU - Hartley, Andrew

AU - Fresco, Lydia

AU - Hoda Al-Booz, Hoda

AU - Junor, Liz

AU - El-Hariry, Iman

AU - Roberts, Sally

AU - Harrington, Kevin

AU - Ang, Kie-Kian

AU - Dunn, Janet

AU - Woodman, Ciaran

PY - 2016/4/25

Y1 - 2016/4/25

N2 - Background: There are variations in the proportions of head and neck cancers (HNC) caused by the Human Papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.Methods: We tested FFPE diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by PCR and ISH) using validated protocols on samples from 801 HNC patients recruited prospectively between 2006 – 2011 in 4 RCTs. Results: 21% (170/801) showed both HPV-DNA and p16 positivity, detected almost exclusively in oropharyngeal cancer (OPC) (55%, 15/302); only 1%, (5/499) non-OPC were positive. HPV OPC differed between Western and Eastern Europe (37%, 155/422vs 6%, 8/144 p<0.0001) and between Western Europe and Asia (37% vs 2%, 4/217, p<0·0001). Other independent determinants of HPV positivity were tumour site and smoking. Conclusions: This is the first study to establish geographic variability as an independent risk factor in HPV OPC prevalence, with higher prevalence in Western Europe.

AB - Background: There are variations in the proportions of head and neck cancers (HNC) caused by the Human Papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.Methods: We tested FFPE diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by PCR and ISH) using validated protocols on samples from 801 HNC patients recruited prospectively between 2006 – 2011 in 4 RCTs. Results: 21% (170/801) showed both HPV-DNA and p16 positivity, detected almost exclusively in oropharyngeal cancer (OPC) (55%, 15/302); only 1%, (5/499) non-OPC were positive. HPV OPC differed between Western and Eastern Europe (37%, 155/422vs 6%, 8/144 p<0.0001) and between Western Europe and Asia (37% vs 2%, 4/217, p<0·0001). Other independent determinants of HPV positivity were tumour site and smoking. Conclusions: This is the first study to establish geographic variability as an independent risk factor in HPV OPC prevalence, with higher prevalence in Western Europe.

KW - Oropharnx

KW - Head

KW - Neck

KW - Cancer

KW - squamous

KW - cell

KW - carcinom

KW - human

KW - Papillomavirus

U2 - 10.1002/hed.24336

DO - 10.1002/hed.24336

M3 - Article

C2 - 26749143

SN - 1043-3074

VL - 38

SP - E1863–E1869

JO - Head & Neck

JF - Head & Neck

IS - S1

ER -

Geographic variation in human papillomavirus–related oropharyngeal cancer: data from four multinational randomized trials

Abstract

Keywords

UN SDGs

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