TY - JOUR
T1 - Genomic analysis of protein?DNA interactions in bacteria: insights into transcription and chromosome organization
AU - Wade, JT
AU - Struhl, K
AU - Busby, Stephen
AU - Grainger, David
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein-DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA-protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.
AB - Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein-DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA-protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.
U2 - 10.1111/j.1365-2958.2007.05781.x
DO - 10.1111/j.1365-2958.2007.05781.x
M3 - Review article
C2 - 17581117
SN - 1365-2958
VL - 65
SP - 21
EP - 26
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 1
ER -