Genome-wide eQTLs and heritability for gene expression traits in unrelated individuals

Research output: Contribution to journalArticle

Authors

  • Shengjie Yang
  • Yiyuan Liu
  • Ning Jiang
  • Jing Chen
  • Minghui Wang

Colleges, School and Institutes

Abstract

While the possible sources underlying the so-called 'missing heritability' evident in current genome-wide association studies (GWAS) of complex traits have been actively pursued in recent years, resolving this mystery remains a challenging task. Studying heritability of genome-wide gene expression traits can shed light on the goal of understanding the relationship between phenotype and genotype. Here we used microarray gene expression measurements of lymphoblastoid cell lines and genome-wide SNP genotype data from 210 HapMap individuals to examine the heritability of gene expression traits.

Details

Original languageEnglish
Article number13
JournalBMC Genomics
Volume15
Issue number1
Publication statusPublished - 9 Jan 2014