Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. / Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben; Winsvold, Bendik S.; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John Anker; Strand, Linn B.; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa.

In: Nature Communications, Vol. 10, 3503, 13.08.2019.

Research output: Contribution to journalArticle

Harvard

Wang, H, Lane, JM, Jones, SE, Dashti, HS, Ollila, HM, Wood, AR, van Hees, VT, Brumpton, B, Winsvold, BS, Kantojärvi, K, Palviainen, T, Cade, BE, Sofer, T, Song, Y, Patel, K, Anderson, SG, Bechtold, DA, Bowden, J, Emsley, R, Kyle, SD, Little, MA, Loudon, AS, Scheer, FAJL, Purcell, SM, Richmond, RC, Spiegelhalder, K, Tyrrell, J, Zhu, X, Hublin, C, Kaprio, JA, Kristiansson, K, Sulkava, S, Paunio, T, Hveem, K, Nielsen, JB, Willer, CJ, Zwart, JA, Strand, LB, Frayling, TM, Ray, D, Lawlor, DA, Rutter, MK, Weedon, MN, Redline, S & Saxena, R 2019, 'Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes', Nature Communications, vol. 10, 3503. https://doi.org/10.1038/s41467-019-11456-7

APA

Wang, H., Lane, J. M., Jones, S. E., Dashti, H. S., Ollila, H. M., Wood, A. R., van Hees, V. T., Brumpton, B., Winsvold, B. S., Kantojärvi, K., Palviainen, T., Cade, B. E., Sofer, T., Song, Y., Patel, K., Anderson, S. G., Bechtold, D. A., Bowden, J., Emsley, R., ... Saxena, R. (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10, [3503]. https://doi.org/10.1038/s41467-019-11456-7

Vancouver

Author

Wang, Heming ; Lane, Jacqueline M. ; Jones, Samuel E. ; Dashti, Hassan S. ; Ollila, Hanna M. ; Wood, Andrew R. ; van Hees, Vincent T. ; Brumpton, Ben ; Winsvold, Bendik S. ; Kantojärvi, Katri ; Palviainen, Teemu ; Cade, Brian E. ; Sofer, Tamar ; Song, Yanwei ; Patel, Krunal ; Anderson, Simon G. ; Bechtold, David A. ; Bowden, Jack ; Emsley, Richard ; Kyle, Simon D. ; Little, Max A. ; Loudon, Andrew S. ; Scheer, Frank A.J.L. ; Purcell, Shaun M. ; Richmond, Rebecca C. ; Spiegelhalder, Kai ; Tyrrell, Jessica ; Zhu, Xiaofeng ; Hublin, Christer ; Kaprio, Jaakko A. ; Kristiansson, Kati ; Sulkava, Sonja ; Paunio, Tiina ; Hveem, Kristian ; Nielsen, Jonas B. ; Willer, Cristen J. ; Zwart, John Anker ; Strand, Linn B. ; Frayling, Timothy M. ; Ray, David ; Lawlor, Deborah A. ; Rutter, Martin K. ; Weedon, Michael N. ; Redline, Susan ; Saxena, Richa. / Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. In: Nature Communications. 2019 ; Vol. 10.

Bibtex

@article{045ec89b942945caa72efe4f8aec0113,
title = "Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes",
abstract = "Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.",
author = "Heming Wang and Lane, {Jacqueline M.} and Jones, {Samuel E.} and Dashti, {Hassan S.} and Ollila, {Hanna M.} and Wood, {Andrew R.} and {van Hees}, {Vincent T.} and Ben Brumpton and Winsvold, {Bendik S.} and Katri Kantoj{\"a}rvi and Teemu Palviainen and Cade, {Brian E.} and Tamar Sofer and Yanwei Song and Krunal Patel and Anderson, {Simon G.} and Bechtold, {David A.} and Jack Bowden and Richard Emsley and Kyle, {Simon D.} and Little, {Max A.} and Loudon, {Andrew S.} and Scheer, {Frank A.J.L.} and Purcell, {Shaun M.} and Richmond, {Rebecca C.} and Kai Spiegelhalder and Jessica Tyrrell and Xiaofeng Zhu and Christer Hublin and Kaprio, {Jaakko A.} and Kati Kristiansson and Sonja Sulkava and Tiina Paunio and Kristian Hveem and Nielsen, {Jonas B.} and Willer, {Cristen J.} and Zwart, {John Anker} and Strand, {Linn B.} and Frayling, {Timothy M.} and David Ray and Lawlor, {Deborah A.} and Rutter, {Martin K.} and Weedon, {Michael N.} and Susan Redline and Richa Saxena",
year = "2019",
month = aug
day = "13",
doi = "10.1038/s41467-019-11456-7",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

AU - Wang, Heming

AU - Lane, Jacqueline M.

AU - Jones, Samuel E.

AU - Dashti, Hassan S.

AU - Ollila, Hanna M.

AU - Wood, Andrew R.

AU - van Hees, Vincent T.

AU - Brumpton, Ben

AU - Winsvold, Bendik S.

AU - Kantojärvi, Katri

AU - Palviainen, Teemu

AU - Cade, Brian E.

AU - Sofer, Tamar

AU - Song, Yanwei

AU - Patel, Krunal

AU - Anderson, Simon G.

AU - Bechtold, David A.

AU - Bowden, Jack

AU - Emsley, Richard

AU - Kyle, Simon D.

AU - Little, Max A.

AU - Loudon, Andrew S.

AU - Scheer, Frank A.J.L.

AU - Purcell, Shaun M.

AU - Richmond, Rebecca C.

AU - Spiegelhalder, Kai

AU - Tyrrell, Jessica

AU - Zhu, Xiaofeng

AU - Hublin, Christer

AU - Kaprio, Jaakko A.

AU - Kristiansson, Kati

AU - Sulkava, Sonja

AU - Paunio, Tiina

AU - Hveem, Kristian

AU - Nielsen, Jonas B.

AU - Willer, Cristen J.

AU - Zwart, John Anker

AU - Strand, Linn B.

AU - Frayling, Timothy M.

AU - Ray, David

AU - Lawlor, Deborah A.

AU - Rutter, Martin K.

AU - Weedon, Michael N.

AU - Redline, Susan

AU - Saxena, Richa

PY - 2019/8/13

Y1 - 2019/8/13

N2 - Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.

AB - Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.

UR - http://www.scopus.com/inward/record.url?scp=85070777691&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-11456-7

DO - 10.1038/s41467-019-11456-7

M3 - Article

C2 - 31409809

AN - SCOPUS:85070777691

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 3503

ER -