TY - JOUR
T1 - Genetics of Parkinson's disease and parkinsonism
AU - Douglas, Michael
AU - Lewthwaite, Alistair
AU - Nicholl, David
PY - 2007/6/1
Y1 - 2007/6/1
N2 - The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.
AB - The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.
U2 - 10.1586/14737175.7.6.657
DO - 10.1586/14737175.7.6.657
M3 - Review article
C2 - 17563249
SN - 1744-8360
SN - 1744-8360
SN - 1744-8360
SN - 1744-8360
VL - 7
SP - 657
EP - 666
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 6
ER -