Genetic Vulnerability to Affective Psychopathology in Childhood: A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study

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Genetic Vulnerability to Affective Psychopathology in Childhood : A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study. / Mechelli, Andrea; Tognin, Stefania; McGuire, Philip K.; Prata, Diana; Sartori, Giuseppe; Fusar-Poli, Paolo; De Brito, Stephane; Hariri, Ahmad R.; Viding, Essi.

In: Biological Psychiatry, Vol. 66, No. 3, 01.08.2009, p. 231-237.

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Mechelli, Andrea ; Tognin, Stefania ; McGuire, Philip K. ; Prata, Diana ; Sartori, Giuseppe ; Fusar-Poli, Paolo ; De Brito, Stephane ; Hariri, Ahmad R. ; Viding, Essi. / Genetic Vulnerability to Affective Psychopathology in Childhood : A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study. In: Biological Psychiatry. 2009 ; Vol. 66, No. 3. pp. 231-237.

Bibtex

@article{007364e93eeb4445a468bb6e61a0e97e,
title = "Genetic Vulnerability to Affective Psychopathology in Childhood: A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study",
abstract = "Background: The majority of affective psychopathology is rooted early in life and first emerges during childhood and adolescence. However, little is known about how genetic vulnerability affects brain structure and function in childhood since the vast majority of studies published so far have been conducted on adult participants. The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methods: Voxel-based morphometry and functional magnetic resonance imaging were used to measure gray matter volume and emotional reactivity in 50 children aged between 10 and 12 years. We tested the hypothesis that met158 allele affects structural brain development and confers heightened reactivity within the affective frontolimbic circuit in children. Results: The met158 allele was positively associated with gray matter volume in the left hippocampal head where genotype accounted for 59% of interindividual variance. In addition, the met158 allele was positively associated with neuronal responses to fearful relative to neutral facial expressions in the right parahippocampal gyrus where genotype accounted for 14% of the interindividual variance. Conclusions: These results indicate that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age. These findings are consistent with the notion that genetic factors affect brain function to moderate vulnerability to affective psychopathology from childhood.",
keywords = "Affective psychopathology, childhood, COMT, emotional processing, hippocampus",
author = "Andrea Mechelli and Stefania Tognin and McGuire, {Philip K.} and Diana Prata and Giuseppe Sartori and Paolo Fusar-Poli and {De Brito}, Stephane and Hariri, {Ahmad R.} and Essi Viding",
year = "2009",
month = aug,
day = "1",
doi = "10.1016/j.biopsych.2009.01.033",
language = "English",
volume = "66",
pages = "231--237",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Genetic Vulnerability to Affective Psychopathology in Childhood

T2 - A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study

AU - Mechelli, Andrea

AU - Tognin, Stefania

AU - McGuire, Philip K.

AU - Prata, Diana

AU - Sartori, Giuseppe

AU - Fusar-Poli, Paolo

AU - De Brito, Stephane

AU - Hariri, Ahmad R.

AU - Viding, Essi

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: The majority of affective psychopathology is rooted early in life and first emerges during childhood and adolescence. However, little is known about how genetic vulnerability affects brain structure and function in childhood since the vast majority of studies published so far have been conducted on adult participants. The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methods: Voxel-based morphometry and functional magnetic resonance imaging were used to measure gray matter volume and emotional reactivity in 50 children aged between 10 and 12 years. We tested the hypothesis that met158 allele affects structural brain development and confers heightened reactivity within the affective frontolimbic circuit in children. Results: The met158 allele was positively associated with gray matter volume in the left hippocampal head where genotype accounted for 59% of interindividual variance. In addition, the met158 allele was positively associated with neuronal responses to fearful relative to neutral facial expressions in the right parahippocampal gyrus where genotype accounted for 14% of the interindividual variance. Conclusions: These results indicate that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age. These findings are consistent with the notion that genetic factors affect brain function to moderate vulnerability to affective psychopathology from childhood.

AB - Background: The majority of affective psychopathology is rooted early in life and first emerges during childhood and adolescence. However, little is known about how genetic vulnerability affects brain structure and function in childhood since the vast majority of studies published so far have been conducted on adult participants. The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methods: Voxel-based morphometry and functional magnetic resonance imaging were used to measure gray matter volume and emotional reactivity in 50 children aged between 10 and 12 years. We tested the hypothesis that met158 allele affects structural brain development and confers heightened reactivity within the affective frontolimbic circuit in children. Results: The met158 allele was positively associated with gray matter volume in the left hippocampal head where genotype accounted for 59% of interindividual variance. In addition, the met158 allele was positively associated with neuronal responses to fearful relative to neutral facial expressions in the right parahippocampal gyrus where genotype accounted for 14% of the interindividual variance. Conclusions: These results indicate that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age. These findings are consistent with the notion that genetic factors affect brain function to moderate vulnerability to affective psychopathology from childhood.

KW - Affective psychopathology

KW - childhood

KW - COMT

KW - emotional processing

KW - hippocampus

UR - http://www.scopus.com/inward/record.url?scp=67649413138&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2009.01.033

DO - 10.1016/j.biopsych.2009.01.033

M3 - Article

C2 - 19278671

AN - SCOPUS:67649413138

VL - 66

SP - 231

EP - 237

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 3

ER -