Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data

Alena Kushniarevich; Olga Utevska; Marina Chuhryaeva; Anastasia Agdzhoyan; Khadizhat Dibirova; Ingrida Uktveryte; Märt Möls; Lejla Mulahasanovic; Andrey Pshenichnov; Svetlana Frolova; Andrey Shanko; Ene Metspalu; Maere Reidla; Kristiina Tambets; Erika Tamm; Sergey Koshel; Valery Zaporozhchenko; Lubov Atramentova; Vaidutis Kučinskas; Oleg Davydenko; Olga Goncharova; Irina Evseeva; Michail Churnosov; Elvira Pocheshchova; Bayazit Yunusbayev; Elza Khusnutdinova; Damir Marjanović; Pavao Rudan; Siiri Rootsi; Nick Yankovsky; Phillip Endicott; Alexei Kassian; Anna Dybo; Chris Tyler-Smith; Elena Balanovska; Mait Metspalu; Toomas Kivisild; Richard Villems; Oleg Balanovsky; Li Jin; Hui Li; Shilin Li; Pandikumar Swamikrishnan; Asif Javed; Laxmi Parida; Ajay K. Royyuru; R. John Mitchell; Pierre A. Zalloua; Syama Adhikarla; Arun Kumar; Ganesh Prasad; Ramasamy Pitchappan; Arun Varatharajan Santhakumari; R. Spencer Wells; Miguel G. Vilar; Himla Soodyall; Daniela R. Lacerda; Fabrício R. Santos; Jaume Bertranpetit; Marc Haber; Marta Melé; Christina J. Adler; Alan Cooper; Clio S.I. Der Sarkissian; Wolfgang Haak; Matthew E. Kaplan; Nirav C. Merchant; Colin Renfrew; Andrew C. Clarke; Elizabeth A. Matisoo-Smith; Jill B. Gaieski; Amanda C. Owings; Theodore G. Schurr

doi:10.1371/journal.pone.0135820

Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data

Alena Kushniarevich, Olga Utevska, Marina Chuhryaeva, Anastasia Agdzhoyan, Khadizhat Dibirova, Ingrida Uktveryte, Märt Möls, Lejla Mulahasanovic, Andrey Pshenichnov, Svetlana Frolova, Andrey Shanko, Ene Metspalu, Maere Reidla, Kristiina Tambets, Erika Tamm, Sergey Koshel, Valery Zaporozhchenko, Lubov Atramentova, Vaidutis Kučinskas, Oleg DavydenkoOlga Goncharova, Irina Evseeva, Michail Churnosov, Elvira Pocheshchova, Bayazit Yunusbayev, Elza Khusnutdinova, Damir Marjanović, Pavao Rudan, Siiri Rootsi, Nick Yankovsky, Phillip Endicott, Alexei Kassian, Anna Dybo, Chris Tyler-Smith, Elena Balanovska, Mait Metspalu, Toomas Kivisild, Richard Villems, Oleg Balanovsky, Li Jin, Hui Li, Shilin Li, Pandikumar Swamikrishnan, Asif Javed, Laxmi Parida, Ajay K. Royyuru, R. John Mitchell, Pierre A. Zalloua, Syama Adhikarla, Arun Kumar, Ganesh Prasad, Ramasamy Pitchappan, Arun Varatharajan Santhakumari, R. Spencer Wells, Miguel G. Vilar, Himla Soodyall, Daniela R. Lacerda, Fabrício R. Santos, Jaume Bertranpetit, Marc Haber, Marta Melé, Christina J. Adler, Alan Cooper, Clio S.I. Der Sarkissian, Wolfgang Haak, Matthew E. Kaplan, Nirav C. Merchant, Colin Renfrew, Andrew C. Clarke, Elizabeth A. Matisoo-Smith, Jill B. Gaieski, Amanda C. Owings, Theodore G. Schurr

Cancer and Genomic Sciences

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Abstract

The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion-mainly to East Europe and the northern Balkans-resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: 'central-east European' for West and East Slavs, and 'south-east European' for South Slavs. A pattern of distribution of segments identical by descent between groups of East-West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.

Original language	English
Article number	e0135820
Number of pages	19
Journal	PLoS ONE
Volume	10
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0135820
Publication status	Published - 2 Sept 2015

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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Kushniarevich, A., Utevska, O., Chuhryaeva, M., Agdzhoyan, A., Dibirova, K., Uktveryte, I., Möls, M., Mulahasanovic, L., Pshenichnov, A., Frolova, S., Shanko, A., Metspalu, E., Reidla, M., Tambets, K., Tamm, E., Koshel, S., Zaporozhchenko, V., Atramentova, L., Kučinskas, V., ... Schurr, T. G. (2015). Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data. PLoS ONE, 10(9), Article e0135820. https://doi.org/10.1371/journal.pone.0135820

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title = "Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data",

abstract = "The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion-mainly to East Europe and the northern Balkans-resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: 'central-east European' for West and East Slavs, and 'south-east European' for South Slavs. A pattern of distribution of segments identical by descent between groups of East-West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.",

author = "Alena Kushniarevich and Olga Utevska and Marina Chuhryaeva and Anastasia Agdzhoyan and Khadizhat Dibirova and Ingrida Uktveryte and M{\"a}rt M{\"o}ls and Lejla Mulahasanovic and Andrey Pshenichnov and Svetlana Frolova and Andrey Shanko and Ene Metspalu and Maere Reidla and Kristiina Tambets and Erika Tamm and Sergey Koshel and Valery Zaporozhchenko and Lubov Atramentova and Vaidutis Ku{\v c}inskas and Oleg Davydenko and Olga Goncharova and Irina Evseeva and Michail Churnosov and Elvira Pocheshchova and Bayazit Yunusbayev and Elza Khusnutdinova and Damir Marjanovi{\'c} and Pavao Rudan and Siiri Rootsi and Nick Yankovsky and Phillip Endicott and Alexei Kassian and Anna Dybo and Chris Tyler-Smith and Elena Balanovska and Mait Metspalu and Toomas Kivisild and Richard Villems and Oleg Balanovsky and Li Jin and Hui Li and Shilin Li and Pandikumar Swamikrishnan and Asif Javed and Laxmi Parida and Royyuru, {Ajay K.} and Mitchell, {R. John} and Zalloua, {Pierre A.} and Syama Adhikarla and Arun Kumar and Ganesh Prasad and Ramasamy Pitchappan and Santhakumari, {Arun Varatharajan} and Wells, {R. Spencer} and Vilar, {Miguel G.} and Himla Soodyall and Lacerda, {Daniela R.} and Santos, {Fabr{\'i}cio R.} and Jaume Bertranpetit and Marc Haber and Marta Mel{\'e} and Adler, {Christina J.} and Alan Cooper and {Der Sarkissian}, {Clio S.I.} and Wolfgang Haak and Kaplan, {Matthew E.} and Merchant, {Nirav C.} and Colin Renfrew and Clarke, {Andrew C.} and Matisoo-Smith, {Elizabeth A.} and Gaieski, {Jill B.} and Owings, {Amanda C.} and Schurr, {Theodore G.}",

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Kushniarevich, A, Utevska, O, Chuhryaeva, M, Agdzhoyan, A, Dibirova, K, Uktveryte, I, Möls, M, Mulahasanovic, L, Pshenichnov, A, Frolova, S, Shanko, A, Metspalu, E, Reidla, M, Tambets, K, Tamm, E, Koshel, S, Zaporozhchenko, V, Atramentova, L, Kučinskas, V, Davydenko, O, Goncharova, O, Evseeva, I, Churnosov, M, Pocheshchova, E, Yunusbayev, B, Khusnutdinova, E, Marjanović, D, Rudan, P, Rootsi, S, Yankovsky, N, Endicott, P, Kassian, A, Dybo, A, Tyler-Smith, C, Balanovska, E, Metspalu, M, Kivisild, T, Villems, R, Balanovsky, O, Jin, L, Li, H, Li, S, Swamikrishnan, P, Javed, A, Parida, L, Royyuru, AK, Mitchell, RJ, Zalloua, PA, Adhikarla, S, Kumar, A, Prasad, G, Pitchappan, R, Santhakumari, AV, Wells, RS, Vilar, MG, Soodyall, H, Lacerda, DR, Santos, FR, Bertranpetit, J, Haber, M, Melé, M, Adler, CJ, Cooper, A, Der Sarkissian, CSI, Haak, W, Kaplan, ME, Merchant, NC, Renfrew, C, Clarke, AC, Matisoo-Smith, EA, Gaieski, JB, Owings, AC & Schurr, TG 2015, 'Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data', PLoS ONE, vol. 10, no. 9, e0135820. https://doi.org/10.1371/journal.pone.0135820

TY - JOUR

T1 - Genetic heritage of the Balto-Slavic speaking populations

T2 - a synthesis of autosomal, mitochondrial and Y-chromosomal data

AU - Kushniarevich, Alena

AU - Utevska, Olga

AU - Chuhryaeva, Marina

AU - Agdzhoyan, Anastasia

AU - Dibirova, Khadizhat

AU - Uktveryte, Ingrida

AU - Möls, Märt

AU - Mulahasanovic, Lejla

AU - Pshenichnov, Andrey

AU - Frolova, Svetlana

AU - Shanko, Andrey

AU - Metspalu, Ene

AU - Reidla, Maere

AU - Tambets, Kristiina

AU - Tamm, Erika

AU - Koshel, Sergey

AU - Zaporozhchenko, Valery

AU - Atramentova, Lubov

AU - Kučinskas, Vaidutis

AU - Davydenko, Oleg

AU - Goncharova, Olga

AU - Evseeva, Irina

AU - Churnosov, Michail

AU - Pocheshchova, Elvira

AU - Yunusbayev, Bayazit

AU - Khusnutdinova, Elza

AU - Marjanović, Damir

AU - Rudan, Pavao

AU - Rootsi, Siiri

AU - Yankovsky, Nick

AU - Endicott, Phillip

AU - Kassian, Alexei

AU - Dybo, Anna

AU - Tyler-Smith, Chris

AU - Balanovska, Elena

AU - Metspalu, Mait

AU - Kivisild, Toomas

AU - Villems, Richard

AU - Balanovsky, Oleg

AU - Jin, Li

AU - Li, Hui

AU - Li, Shilin

AU - Swamikrishnan, Pandikumar

AU - Javed, Asif

AU - Parida, Laxmi

AU - Royyuru, Ajay K.

AU - Mitchell, R. John

AU - Zalloua, Pierre A.

AU - Adhikarla, Syama

AU - Kumar, Arun

AU - Prasad, Ganesh

AU - Pitchappan, Ramasamy

AU - Santhakumari, Arun Varatharajan

AU - Wells, R. Spencer

AU - Vilar, Miguel G.

AU - Soodyall, Himla

AU - Lacerda, Daniela R.

AU - Santos, Fabrício R.

AU - Bertranpetit, Jaume

AU - Haber, Marc

AU - Melé, Marta

AU - Adler, Christina J.

AU - Cooper, Alan

AU - Der Sarkissian, Clio S.I.

AU - Haak, Wolfgang

AU - Kaplan, Matthew E.

AU - Merchant, Nirav C.

AU - Renfrew, Colin

AU - Clarke, Andrew C.

AU - Matisoo-Smith, Elizabeth A.

AU - Gaieski, Jill B.

AU - Owings, Amanda C.

AU - Schurr, Theodore G.

PY - 2015/9/2

Y1 - 2015/9/2

N2 - The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion-mainly to East Europe and the northern Balkans-resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: 'central-east European' for West and East Slavs, and 'south-east European' for South Slavs. A pattern of distribution of segments identical by descent between groups of East-West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.

AB - The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion-mainly to East Europe and the northern Balkans-resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: 'central-east European' for West and East Slavs, and 'south-east European' for South Slavs. A pattern of distribution of segments identical by descent between groups of East-West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.

UR - http://www.scopus.com/inward/record.url?scp=84947461238&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0135820

DO - 10.1371/journal.pone.0135820

M3 - Article

C2 - 26332464

AN - SCOPUS:84947461238

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 9

M1 - e0135820

ER -

Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data

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