TY - JOUR
T1 - Genes required for systemic RNA interference in Caenorhabditis elegans
AU - Tijsterman, M
AU - May, Robin
AU - Simmer, F
AU - Okihara, KL
AU - Plasterk, RH
PY - 2004/1/1
Y1 - 2004/1/1
N2 - RNA interference (RNAi) in the nematode worm, Caenorhabditis elegans, occurs systemically. Double-stranded RNA (dsRNA) provided in the diet can be absorbed from the gut lumen and distributed throughout the body, triggering RNAi in tissues that are not exposed to the initial dsRNA trigger. This is in marked contrast to other animals, in which RNAi does not spread from targeted tissues to neighboring cells. Here, we report the characterization of mutants defective in the systemic aspect of RNAi, but not in the core RNAi process itself. Analysis of these mutants suggests that dsRNA uptake is a specific process involving several unique proteins.
AB - RNA interference (RNAi) in the nematode worm, Caenorhabditis elegans, occurs systemically. Double-stranded RNA (dsRNA) provided in the diet can be absorbed from the gut lumen and distributed throughout the body, triggering RNAi in tissues that are not exposed to the initial dsRNA trigger. This is in marked contrast to other animals, in which RNAi does not spread from targeted tissues to neighboring cells. Here, we report the characterization of mutants defective in the systemic aspect of RNAi, but not in the core RNAi process itself. Analysis of these mutants suggests that dsRNA uptake is a specific process involving several unique proteins.
UR - http://www.scopus.com/inward/record.url?scp=1142277911&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2003.12.029
DO - 10.1016/j.cub.2003.12.029
M3 - Article
C2 - 14738731
SN - 1879-0445
VL - 14
SP - 111
EP - 116
JO - Current Biology
JF - Current Biology
IS - 2
ER -