Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

JR Mora; Johannes Eksteen; M Iwata; S-Y Song; T Junt; B Senman; KL Otipoby; A Yokota; H Takeuchi; P Ricciardi-Castagnoli; K Rajewski; David Adams; UH Von Andrian

doi:10.1126/science.1132742

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

JR Mora, Johannes Eksteen, M Iwata, S-Y Song, T Junt, B Senman, KL Otipoby, A Yokota, H Takeuchi, P Ricciardi-Castagnoli, K Rajewski, David Adams, UH Von Andrian

Immunology and Immunotherapy

Research output: Contribution to journal › Article

720 Citations (Scopus)

Abstract

Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

Original language	English
Pages (from-to)	1157-60
Number of pages	4
Journal	Science
Volume	314
DOIs	https://doi.org/10.1126/science.1132742
Publication status	Published - 17 Nov 2006

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10.1126/science.1132742

Mucosal Lymphocytes in the Pathogenesis of Primary Sclerosing Cholangitis
Eksteen, B.
Medical Research Council
1/10/07 → 31/03/13
Project: Research Councils

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title = "Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells",

abstract = "Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.",

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AU - Mora, JR

AU - Eksteen, Johannes

AU - Iwata, M

AU - Song, S-Y

AU - Junt, T

AU - Senman, B

AU - Otipoby, KL

AU - Yokota, A

AU - Takeuchi, H

AU - Ricciardi-Castagnoli, P

AU - Rajewski, K

AU - Adams, David

AU - Von Andrian, UH

PY - 2006/11/17

Y1 - 2006/11/17

N2 - Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

AB - Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

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Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

Abstract

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Mucosal Lymphocytes in the Pathogenesis of Primary Sclerosing Cholangitis

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