Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

Research output: Contribution to journalArticle

Authors

  • JR Mora
  • M Iwata
  • S-Y Song
  • T Junt
  • B Senman
  • KL Otipoby
  • A Yokota
  • H Takeuchi
  • P Ricciardi-Castagnoli
  • K Rajewski
  • UH Von Andrian

Colleges, School and Institutes

Abstract

Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

Details

Original languageEnglish
Pages (from-to)1157-60
Number of pages4
JournalScience
Volume314
Publication statusPublished - 17 Nov 2006