Generation of diversity in thymic epithelial cells

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Generation of diversity in thymic epithelial cells. / Takahama, Yousuke; Ohigashi, Izumi; Baik, Song; Anderson, Graham.

In: Nature Reviews Immunology, Vol. 17, 20.03.2017, p. 295-305.

Research output: Contribution to journalReview articlepeer-review

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Takahama, Yousuke ; Ohigashi, Izumi ; Baik, Song ; Anderson, Graham. / Generation of diversity in thymic epithelial cells. In: Nature Reviews Immunology. 2017 ; Vol. 17. pp. 295-305.

Bibtex

@article{310cb66b703e47c29189648df07b5b42,
title = "Generation of diversity in thymic epithelial cells",
abstract = "In the thymus, diverse populations of thymic epithelial cells (TECs), includingcortical and medullary TECs and their subpopulations, have distinct roles incoordinating the development and repertoire selection of functionally competentand self-tolerant T cells. Here, we review the expanding diversity in TECsubpopulations, in relation to their functions in T cell development and selectionas well as their origins and development.",
keywords = "T cells, Thymus",
author = "Yousuke Takahama and Izumi Ohigashi and Song Baik and Graham Anderson",
year = "2017",
month = mar,
day = "20",
doi = "10.1038/nri.2017.12",
language = "English",
volume = "17",
pages = "295--305",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Generation of diversity in thymic epithelial cells

AU - Takahama, Yousuke

AU - Ohigashi, Izumi

AU - Baik, Song

AU - Anderson, Graham

PY - 2017/3/20

Y1 - 2017/3/20

N2 - In the thymus, diverse populations of thymic epithelial cells (TECs), includingcortical and medullary TECs and their subpopulations, have distinct roles incoordinating the development and repertoire selection of functionally competentand self-tolerant T cells. Here, we review the expanding diversity in TECsubpopulations, in relation to their functions in T cell development and selectionas well as their origins and development.

AB - In the thymus, diverse populations of thymic epithelial cells (TECs), includingcortical and medullary TECs and their subpopulations, have distinct roles incoordinating the development and repertoire selection of functionally competentand self-tolerant T cells. Here, we review the expanding diversity in TECsubpopulations, in relation to their functions in T cell development and selectionas well as their origins and development.

KW - T cells

KW - Thymus

U2 - 10.1038/nri.2017.12

DO - 10.1038/nri.2017.12

M3 - Review article

C2 - 28317923

VL - 17

SP - 295

EP - 305

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

ER -