Generation of diversity in thymic epithelial cells

Research output: Contribution to journalReview articlepeer-review


Colleges, School and Institutes


In the thymus, diverse populations of thymic epithelial cells (TECs), including
cortical and medullary TECs and their subpopulations, have distinct roles in
coordinating the development and repertoire selection of functionally competent
and self-tolerant T cells. Here, we review the expanding diversity in TEC
subpopulations, in relation to their functions in T cell development and selection
as well as their origins and development.


Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalNature Reviews Immunology
Early online date20 Mar 2017
Publication statusE-pub ahead of print - 20 Mar 2017


  • T cells, Thymus