Abstract
In the thymus, diverse populations of thymic epithelial cells (TECs), including
cortical and medullary TECs and their subpopulations, have distinct roles in
coordinating the development and repertoire selection of functionally competent
and self-tolerant T cells. Here, we review the expanding diversity in TEC
subpopulations, in relation to their functions in T cell development and selection
as well as their origins and development.
cortical and medullary TECs and their subpopulations, have distinct roles in
coordinating the development and repertoire selection of functionally competent
and self-tolerant T cells. Here, we review the expanding diversity in TEC
subpopulations, in relation to their functions in T cell development and selection
as well as their origins and development.
Original language | English |
---|---|
Pages (from-to) | 295-305 |
Number of pages | 11 |
Journal | Nature Reviews Immunology |
Volume | 17 |
Early online date | 20 Mar 2017 |
DOIs | |
Publication status | E-pub ahead of print - 20 Mar 2017 |
Keywords
- T cells
- Thymus